米非司酮联合散结镇痛胶囊治疗子宫内膜异位症患者对性激素水平的影响

摘要

[ABSTRACT]Objective:To investigate the clinical effect of mifepristone combined with loose joint capsule on the treat-ment of endometriosis (EMS)and its effect on sex hormone levels.Methods:A total of 140 cases of EMS in our hospital from 2015.2 to 2016.2 months were selected and randomly divided into treatment group and control group;Control group in men-strual cramps on the 5th day oral mifepristone 12.5 mg each time,once daily,and even served 3 months,the treatment group in the control group based on the combined with Sanjie Zhentong capsule 1.6g/time,3 times daily,even served three months;Acquisition of two groups of patients before treatment and after treatment in the morning fasting venous blood,using ELISA method for the detection of two groups before and after treatment serum follicle stimulation hormone (FSH),luteinizing hor-mone (LH),estradiol (E2 ),and progesterone (P)and adiponectin (ADP)and hepatocyte growth factor (HGF)and observe the incidence of clinical adverse reactions in two groups ResuIts:FSH,LH,E2 and P levels in the two groups after treatment than before treatment was significantly lower (P<0.05),the treatment group after treatment FSH,LH,E2 and P levels was significantly lower than that of the control group (P<0.05);after treatment in the two groups was increased compared with before treatment,the level of ADP and HGF treatment level is decreased (P<0.05),the treatment group after treatment level of ADP and HGF improved better than control group (P<0.05).Treatment of adverse reactions in the treatment group was lower than control group (P<0.05).ConcIusions:Mifepristone Combined with scattered knot analgesia capsule can cure regu-lating sex hormone level in patients with EMS and inhibit the growth of ectopic endometrium,and decrease the recurrence rate and improve the pregnancy rate.%目的：：探讨米非司酮联合散结镇痛胶囊治疗子宫内膜异位症(EMS)临床疗效及对性激素水平的影响.方法：选取我院2015年2月~2016年2月收治的 EMS 患者140例,采用随机数字表法分为治疗组和对照组,对照组于月经来潮第5天口服米非司酮12．5 mg/次,1次/d,连服3个月,治疗组在对照组基础上联合散结镇痛胶囊1．6 g/次,3次/d,连服3个月；采集两组治疗前、治疗后清晨空腹静脉血,使用ELISA法检测两组治疗前后血清卵泡刺激素(FSH)、促黄体生成素(LH)、雌二醇(E2)、孕酮(P)及脂联素(ADP)、肝细胞生长因子(HGF)水平,并观察两组临床治疗不良反应发生率.结果：两组治疗后FSH、LH、E2、P水平较治疗前明显降低(P＜0．05),治疗组治疗后 FSH、LH、E2、P 水平明显低于对照组(P＜0．05)；两组治疗后ADP水平较治疗前升高,HGF水平较治疗前降低(P＜0．05),治疗组治疗后ADP、HGF水平改善程度优于对照组(P＜0．05).治疗组治疗不良反应发生率低于对照组(P＜0．05).结论：米非司酮联合散结镇痛胶囊能疗调节EMS患者性激素水平,抑制异位子宫内膜的生长,从而降低复发率,提高妊娠率.