Objective:To explore the effects of mild hypothermia combined with minimally invasive surgery on the de-gree of nerve injury and the generation of toxic metabolites in patients with hypertensive cerebral hemorrhage. Methods:138 patients with hypertensive cerebral hemorrhage who received treatment in the hospital between December 2015 and March 2017 were collected and divided into control group(n=69)and mild hypothermia group(n=69)by random number table method. Control group received conventional minimally invasive surgery,and mild hypothermia group received mild hypothermia com-bined with minimally invasive surgery. The differences in the serum contents of nerve injury indexes,excitatory amino acids and oxidative metabolites were compared between two groups of patients before treatment and after 1 week of treatment. Re-sults:There was no statistically significant difference in serum levels of nerve injury indexes,excitatory amino acids and oxida-tive metabolites between the two groups. 1 week after treatment,serum pro-BNP,h-FABP,MBP and NSE levels of mild hy-pothermia group were lower than those of control group;serum excitatory amino acids Glu and Asp levels were lower than those of control group;oxidative metabolites ROS,MDA,AOPPs and LHP levels were lower than those of control group. Conclusion:Mild hypothermia combined with minimally invasive surgery can effectively relieve the nerve injury and reduce the secretion of excitatory amino acids,oxidative metabolites and so on in patients with hypertensive cerebral hemorrhage.%目的:探讨亚低温联合微创手术对高血压脑出血患者神经损伤程度及毒副代谢产物生成的影响.方法:收集2015年12月~2017年3年间在本院接受治疗的高血压脑出血患者138例,经随机数表法分为对照组、亚低温组各69例.对照组患者接受常规微创手术治疗,亚低温组患者接受亚低温联合微创手术治疗.对比两组患者治疗前、治疗后1周血清中神经损伤指标、兴奋性氨基酸、氧化代谢产物含量的差异.结果:治疗前,两组患者血清中神经损伤指标、兴奋性氨基酸、氧化代谢产物含量的差异无统计学意义.治疗后1周,亚低温组血清中pro-BNP、h-FABP、MBP、NSE的含量低于对照组;血清中兴奋性氨基酸Glu、Asp的含量低于对照组;氧化代谢产物ROS、MDA、AOPPs、LHP的含量低于对照组.结论:高血压脑出血患者接受亚低温联合微创手术治疗,可有效减轻神经损伤并减少兴奋性氨基酸、氧化代谢产物等分泌.
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