MODULATION OF THE EXPRESSION OF TOLL-LIKE RECEPTORS INFLUENCES NEURODEGENERATION AND NEUROPROTECTION IN THE HUMAN CENTRAL NERVOUS SYSTEM

摘要

The invention provides a method for modifying the expression of at least one Toll-like receptor (TLR) in cells of the human central nervous system (CNS) comprising contacting said cells with a TLR-expression modifying agent selected from the group consisting of substances that are endogenous to the human CNS, and parts or variants thereof that are capable of altering the expression of a TLR in said cells. The invention also provides a method for retarding or inhibiting a neurodegenerative process and/or stimulating a neuroprotective process in a human being afflicted by a neurodegenerative disorder, comprising administering to said human being a TLR-expression modifying agent selected from the group consisting of substances that are endogenous to the human CNS, and parts or variants thereof that are capable of altering the expression of a TLR in cells of said CNS.