Objective: To study the effect of compound α-ketoacid combined with routine nutritional intervention on the inflammatory response and oxidative stress response in patients with maintenance hemodialysis.Methods: A total of 78 patients with uremia who received maintenance hemodialysis in Dangyang Changbanpo Hospital were collected and divided into control group and observation group according to the random number table method, 39 cases in each group.The control group received routine nutritional intervention, and the observation group underwent compound α-ketoacid combined with routine nutritional intervention.The serum levels of inflammatory factors and oxidative stress indicators in two groups of patients were detected before dialysis and 6 months after dialysis.Results: Before dialysis, differences in serum levels of inflammatory factors and oxidative stress indexes were not statistically significant between two groups of patients (P>0.05).After dialysis, serum CRP, IL-6, TNF-α, MDA and AOPP levels of both groups of patients were higher than those before dialysis while SOD and GSHPx levels were lower than those before dialysis (P<0.05) and serum CRP, IL-6, TNF-α, MDA and AOPP levels of observation group after dialysis were lower than those of control group while SOD and GSHPx levels were higher than those of control group (P<0.05).Conclusions: Compound α-ketoacid combined with routine nutritional intervention can effectively reduce the systemic microinflammatory state and inhibit the oxidative stress response in patients with maintenance hemodialysis.%目的:探讨复方α酮酸联合常规营养干预对维持性血液透析患者炎症反应及氧化应激反应的影响.方法:收集在本院接受维持性血液透析治疗的尿毒症患者78例,按照随机数表法分为对照组、观察组各39例.对照组接受常规营养干预,观察组接受复方α酮酸联合常规营养干预.透析前及透析后6个月,检测两组患者血清中炎症因子、氧化应激指标的含量.结果:透析前,两组血清中炎症因子、氧化应激指标含量比较,差异无统计学意义(P>0.05).透析后,两组血清中CRP、IL-6、TNF-α、MDA、AOPP的含量均高于透析前,SOD、GSHPx的含量均低于透析前(P<0.05),且观察组透析后血清中CRP、IL-6、TNF-α、MDA、AOPP的含量低于对照组,SOD、GSHPx的含量高于对照组(P<0.05).结论:维持性血液透析患者接受复方α酮酸联合常规营养干预能够有效降低全身微炎症状态、抑制氧化应激反应.
展开▼
