SLE患者血清载脂蛋白M含量及与病情活动度的相关性研究

摘要

Objective: To study the correlation of serum APoM (Apolipoprotein M) contents with disease activity for SLE (systemic lupus erythematosus) patients.Methods: A total of 80 SLE patients treated from January 2013 to March 2017 in our Rheumatology and Immunology Department were selected.The subjects were divided into activity group (44 cases) and relief group (36 cases) according to the SLEDAI scores.There were 31 cases with renal injury and 49 cases without renal injury.The index of CRP, ESR, ApoM and blood lipid level for each group was compared.The correlation of ApoM contents with CRP and ESR was analyzed.Results:The index of CRP and ESR for activity group was higher than relief group;the ApoM contents for activity group were lower than relief group (P<0.05);the index of CRP and ESR for renal injury group was higher than non-renal injury group;the ApoM contents for renal injury group was lower than non-renal injury group (P<0.05);the index of TG and LDL-C for activity group were higher than relief group;the index of TC and HDL-C for activity group were lower than relief group (P<0.05);the index of TG and LDL-C for renal injury group was higher than non-renal injury group;the index of TC and HDL-C for renal injury group was lower than non-renal injury group (P<0.05);the ApoM contents were negatively correlated with the index of ESR and CRP (r=-0.584, P<0.001 and r=-0.614,P<0.001).Conclusions: At the activity and relief stages, the ApoM contents for renal injury patients and non-renal injury patients are significantly different;the ApoM contents can be seen as the observation index of SEL activity.It may be correlated with the mediation of inflammatory response.%目的:探讨系统性红斑狼疮(SLE)患者血清载脂蛋白M(ApoM)含量及与病情活动度的相关性.方法:选取2013年1月~2017年3月本院感染免疫收治的SLE患者80例为研究对象,根据SLEDAI评分分为活动组(44例)和缓解组(36例)、肾损组(31例)与无肾损组(49例),比较不同组间C 反应蛋白(CRP)、血沉(ESR)、ApoM及血脂水平,分析ApoM与CRP、ESR间的相关性.结果:活动组CRP、ESR水平高于缓解组,ApoM低于缓解组(P<0.05);肾损组与无肾损组相比,CRP、ESR水平升高,ApoM水平明显降低(P<0.05).活动组甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平高于缓解组,总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)低于缓解组(P<0.05);肾损组与无肾损组相比,前者TG、LDL-C较高,TC、HDL-C下降(P<0.05).SLE患者血清中ApoM水平与ESR、CRP均呈负相关(r=-0.584,P<0.001和r=-0.614,P<0.001).结论:活动期与缓解期SLE 患者、肾损者与非肾损SLE 患者间ApoM水平存在显著差异,ApoM可作为SLE病情活动度的观测指标,原因推测与炎性反应的介导有关.