Objective:To study the correlation of serum APoM (Apolipoprotein M) contents with disease activity for SLE (systemic lupus erythematosus) patients.Method: A total of 80 SLE patients treated from January 2013 to March 2017 in our Rheumatology and Immunology Department were selected. The subjects were divided into activity group (44 cases) and relief group (36 cases) according to the SLEDAI scores. There were 31 cases with renal injury and 49 cases without renal injury. The index of CRP, ESR, ApoM and blood lipid level for each group was compared. The correlation of ApoM contents with CRP and ESR was analyzed.Result:The index of CRP and ESR for activity group was higher than relief group; the ApoM contents for activity group were lower than relief group; the index of CRP and ESR for renal injury group was higher than non-renal injury group; the ApoM contents for renal injury group was lower than non-renal injury group; the index of TG and LDL-C for activity group were higher than relief group; the index of TC and HDL-C for activity group were lower than relief group; the index of TG and LDL-C for renal injury group was higher than non-renal injury group; the index of TC and HDL-C for renal injury group was lower than non-renal injury group; the ApoM contents were negatively correlated with the index of ESR and CRP.Conclusion: At the activity and relief stage,, the ApoM contents for renal injury patients and non-renal injury patients are significantly different; the ApoM contents can be seen as the observation index of SEL activity. It may be correlated with the mediation of inflammatory response.
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