脑反射治疗仪联合针灸对脑梗死患者康复期神经营养状况、神经细胞凋亡情况的影响

摘要

目的:研究脑反射治疗仪联合针灸对脑梗死患者康复期神经营养状况、神经细胞凋亡情况的影响.方法:选择2014年10月~2016年12月期间在新疆医科大学附属中医医院就诊的116例脑梗死康复期患者,随机分为两组,干预组接受脑反射治疗仪联合针灸干预+常规干预,对照组接受常规干预.干预前及干预后10、20、30 d时,检测血清中神经营养细胞因子、单胺类神经递质、神经细胞凋亡分子的含量.结果:两组患者干预后10、20、30 d时血清中脑源性神经营养因子(BDNF)、血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)、NE、E、5-HIAA、DOPAC、HVA、Bcl-2的含量均显著高于治疗前(P<0.05),sFas、sFasL、sTRAIL的含量均显著低于干预前(P<0.05),且干预组患者干预后10、20、30 d时血清中BDNF、VEGF、bFGF、NE、E、5-HIAA、DOPAC、HVA 、Bcl-2的含量均显著高于对照组(P<0.05),sFas、sFasL、sTRAIL的含量均显著低于对照组(P<0.05).结论:脑反射治疗仪联合针灸对脑梗死患者康复期神经营养状况、神经细胞凋亡情况具有显著改善价值.%Objective: To study the effect of brain reflex instrument combined with acupuncture on convalescent neurotrophic status and nerve cell apoptosis in patients with cerebral infarction.Methods: A total of 116 patients with convalescent cerebral infarction who were treated in Chinese Medicine Hospital Affiliated to Xinjiang Medical University between October 2014 and December 2016 were selected and randomly divided into intervention group and control group.Patients in intervention group received brain reflex instrument combined with acupuncture intervention + conventional intervention, while those who were in control group received conventional intervention.Serum levels of neurotrophic cytokines, monoamine neurotransmitter, and nerve cell apoptosis molecules were detected before intervention as well as 10 days, 20 days and 30 days after intervention.Results: Serum BDNF, VEGF, bFGF, NE, E, 5-HIAA, DOPAC, HVA and Bcl-2 levels of both groups 10 days, 20 days and 30 days after intervention were significantly higher than those before intervention(P<0.05)while sFas, sFasL and sTRAIL levels were significantly lower than those before intervention (P<0.05), and serum BDNF, VEGF, bFGF, NE, E, 5-HIAA, DOPAC, HVA and Bcl-2 levels of intervention group 10 days, 20 days and 30 days after intervention were significantly higher than those of control group(P<0.05)while sFas, sFasL and sTRAIL levels were significantly lower than those of control group (P<0.05).Conclusions: Brain reflex instrument combined with acupuncture can significantly improve convalescent neurotrophic status and nerve cell apoptosis in patients with cerebral infarction.