顺铂为基础的同步放化疗对晚期宫颈癌患者恶性程度及原癌基因、抑癌基因表达的影响

摘要

Objective: To study the effect of cisplatin-based concurrent radiochemotherapy on the malignant degree of advanced cervical cancer and the expression of proto-oncogene and tumor suppressor genes.Methods: A total of 82 patients with advanced cervical cancer who were treated in our hospital between July 2013 and December 2016 were collected and divided into control group and observation group according to random number table, 41 cases in each group.The control group received radiotherapy alone, and the observation group received cisplatin-based concurrent radiochemotherapy.Tumor marker levels in serum as well as proto-oncogene and tumor suppressor gene expression in tumor tissue were compared between two groups of patients before and after treatment.Results: Before treatment, differences in tumor marker levels in serum as well as proto-oncogene and tumor suppressor gene expression in tumor tissue were not statistically significant between two groups of patients (P<0.05).After treatment, serum tumor markers SCC, CA50, CA724 and CEA levels of observation group were lower than those of control group;proto-oncogene DEK, c-myc and PIK3CA mRNA expression in tumor tissue were lower than those of control group;tumor suppressor genes p53, SOCS-1, FHIT and PTEN mRNA expression in tumor tissue were significantly higher than those of control group (P<0.05).Conclusion: Cisplatin-based concurrent radiochemotherapy can effectively reduce the tumor malignancy and balance the proto-oncogene / tumor suppressor gene expression in patients with advanced cervical cancer.%目的:探讨顺铂为基础的同步放化疗对晚期宫颈癌患者恶性程度及原癌基因、抑癌基因表达的影响.方法:收集2013年7月~2016年12月间在本院接受治疗的晚期宫颈癌患者82例,按照随机数表法分为对照组、观察组,各41例.对照组患者接受单纯放疗,观察组患者接受顺铂为基础的同步放化疗.对比两组患者治疗前后血清中肿瘤标志物含量,肿瘤组织中原癌基因、抑癌基因表达量的差异.结果:治疗前,两组患者血清中肿瘤标志物含量,肿瘤组织中原癌基因、抑癌基因表达量的差异无统计学意义(P>0.05).治疗后,观察组患者血清中肿瘤标志物鳞状上皮细胞癌相关抗原(SCC)、糖类抗原50(CA50)、糖类抗原724(CA724)、癌胚抗原(CEA)的含量低于对照组患者(P<0.05);肿瘤组织中原癌基因DEK、c-myc、PIK3CA mRNA的表达量低于对照组患者(P<0.05);肿瘤组织中抑癌基因p53、SOCS-1、FHIT、PTEN mRNA的表达量高于对照组患者(P<0.05).结论:晚期宫颈癌患者接受顺铂为基础的同步放化疗,可有效降低肿瘤恶性程度,均衡原癌/抑癌基因的表达.