上皮性卵巢癌患者中血清CA125、HE4、SMRP及细胞因子IL-8、IL-17联合检测意义分析

摘要

目的:分析血清CA125、HE4、SMRP及细胞因子IL-8、IL-17在上皮性卵巢癌(EOC)患者中联合检测的意义.方法:选取我院住院卵巢肿瘤患者83例,其中EOC患者41例,其中卵巢良性肿瘤者42例,选择同期体检的健康者42例为对照组,比较EOC组、卵巢肿瘤良性组及对照组的3种肿瘤标记物和2种细胞因子的表达水平,分析5种标记物在EOC临床病理组织类型及临床分期中的水平.结果:EOC组血清CA125、HE4、SMRP和细胞因子IL-8、IL-17水平均显著高于卵巢肿瘤良性组及健康对照组,差异具有统计学意义(P<0.05),卵巢肿瘤良性组与健康对照组各项指标间比较无显著性差异(P>0.05).EOC患者病理III~IV期患者CA125、HE4、SMRP和细胞因子IL-8、IL-17水平均显著高于病理分期为I~II期EOC患者,差异具有统计学意义(P<0.05). 病理类型为浆液性EOC患者CA125、HE4、SMRP、IL-8、IL-17显著高于病理类型为粘液性EOC患者,CA125、HE4、IL-8显著高于病理类型为内膜样性EOC患者,差异有统计学意义(P<0.05);病理类型为内膜样性EOC患者CA125、HE4、SMRP、IL-17显著高于病理类型为粘液性EOC患者,差异有统计学意义(P<0.05).结论:血清CA125、HE4、SMRP及细胞因子IL-8、IL-17在上皮性卵巢癌中高表达,且与病理分期和病理类型有关,有助于疾病的早期诊断和病情判断.%Objective: To analyze the significanceof join-detection of serum CA125, HE4, SMRP and cytokineIL-8, IL-17 in patientwith epithelial ovarian cancer. Methods: total of 83 patientwith ovarian tumofrom May 2013 to May 2016 in ouhospital were selected. Among these, there are 41 patientwith Eoand 42 patientwith benign ovarian tumor. Athe same time, 42 caseof healthy people from health examination departmenwere selected acontrol group. Expression levelof the 3 tumomarkerand the 2 cytokinewere compared. The levelof the 5 markerin the clinical pathological typeand clinical stageof Eowere analyzed. Results: Serum CA125, HE4, SMRP and cytokineIL-8, IL-17 in Eogroup were (258.47±54.09) U/L, (237.41±12.48) pmol/L, (7.36±2.17) nmol/L, (76.33±9.73) ng/mL, (23.89±7.12) pg/mL, respectively, which were highethan thain the benign ovary tumogroup and healthy control group significantly. And the difference waconsidered to be statistically significan(P<0.05). The comparison of indexebetween benign ovary tumogroup and healthy control group wanoconsidered to be statistically significan(P>0.05). Serum CA125, HE4, SMRP and cytokineIL-8, IL-17 in Eopatientwith Pathological III-IV stage were (382.45±40.74) U/L, (276.19±46.13) pmol/L, (9.36±3.11) nmol/L, (89.06±4.27) ng/mL, (33.52±2.63) pg/mL respectively, which were highethan thain Eopatientwith Pathological I-II stage significantly. And the difference waconsidered to be statistically significan(P<0.05). Serum CA125, HE4, SMRP and cytokineIL-8, IL-17 in Eopatientwith seroutype wasignificantly highethan thain Eopatientwith mucinoutype. CA125, HE4, IL-8 in Eopatientwith seroutype were significantly highethan thain Eopatientwith endometrial type. And the difference waconsidered to be statistically significan(P<0.05). CA125, HE4, SMRP, IL-17 in Eopatientwith endometrial type were highethan thain Eopatientwith mucinoutype. And the difference waconsidered to be statistically significan(P<0.05). Conclusions: The oveexpression of serum CA125, HE4, SMRP and cytokineIL-8, IL-17 in patientwith epithelial ovarian cancewarelated to pathological stage and pathological type, which ihelpful to the early diagnosiand condition judgment.