The significances of join-detection of serum CA125, HE4, SMRP and cytokines IL-8, IL-17 in patients with epithelial ovarian cancer

摘要

Objective:To analyze the significances of join-detection of serum CA125, HE4, SMRP and cytokines IL-8, IL-17 in patients with epithelial ovarian cancer.Methods: A total of 83 patients with ovarian tumor from May 2013 to May 2016 in our hospital were selected. Among these, there are 41 patients with EOC and 42 patients with benign ovarian tumor. At the same time, 42 cases of healthy people from health examination department were selected as control group. Expression levels of the 3 tumor markers and the 2 cytokines were compared. The levels of the 5 markers in the clinical pathological types and clinical stages of EOC were analyzed.Results:Serum CA125, HE4, SMRP and cytokines IL-8, IL-17 in EOC group were (258.47±54.09) U/L, (237.41±12.48) pmol/L, (7.36±2.17) nmol/L, (76.33±9.73) ng/mL, (23.89±7.12) pg/mL, respectively, which were higher than that in the benign ovary tumor group and healthy control group significantly. And the difference was considered to be statistically significant.The comparison of indexes between benign ovary tumor group and healthy control group was not considered to be statistically significant. Serum CA125, HE4, SMRP and cytokines IL-8, IL-17 in EOC patients with Pathological III-IV stage were (382.45±40.74) U/L, (276.19±46.13) pmol/L, (9.36±3.11) nmol/L, (89.06±4.27) ng/mL, (33.52±2.63) pg/mL respectively, which were higher than that in EOC patients with Pathological I-II stage significantly. And the difference was considered to be statistically significant. Serum CA125, HE4, SMRP and cytokines IL-8, IL-17 in EOC patients with serous type was significantly higher than that in EOC patients with mucinous type. And CA125, HE4, IL-8 in EOC patients with serous type were significantly higher than that in EOC patients with endometrial type. And the difference was considered to be statistically significant. CA125, HE4, SMRP, IL-17 in EOC patients with endometrial type were higher than that in EOC patients with mucinous type. And the difference was considered to be statistically significant.Conclusion: The over expression of serum CA125, HE4, SMRP and cytokines IL-8, IL-17 in patients with epithelial ovarian cancer was related to pathological stage and pathological type, which is helpful to the early diagnosis and condition judgment.