[ABSTRACT]Objective:To detect the serum levels of anti-Cyclic Citrullinated Peptide (CCP)antibodies,complement (C3 and C4 )and immunoglobulin (IgG,IgA and IgM)in patients with rheumatoid arthritis (RA).Methods:A total of 100 patients with RA were selected as the observation group,and 60 healthy people were selected as the control group.The RA patients were divided into the high disease active group (25 cases),moderate disease active group (30 cases),low disease active group (24 cases)and remission group (21 cases)according to the disease activity score in 28 joints (DAS28 score).The levels of anti-CCP antibodies,C3 ,C4 ,IgG,IgA and IgM of each research object were detected.Difference of all the serum indexes between the observation group and control group were compared,as well as that between the RA patients in different disease activity states.Finally,the correlation of anti-CCP antibodies with C3 ,C4 ,IgG,IgA and IgM were analyzed.Results:(1)The levels of anti-CCP antibodies [(67.75±21.28)U/mL],C3 [(1.95±1.14)g/L],C4 [(0.63±0.22)g/L],IgG [(18.77±4.83)g/L], IgA [(4.74±1.06)g/L]and IgM [(4.02±0.98)g/L]in the observation group were obviously higher than that in the control group (P <0.05).(2)Compared with RA in remission,the levels of anti-CCP antibodies,C3 ,C4 ,IgG,IgA and IgM of RA in activity were significant higher (P < 0.05 ).Compared with the low disease active group,the levels of anti-CCP antibodies [(73.83±5.28)U/mL and (86.50±6.39)U/mL],C3 [(2.24±0.18)g/L and (2.35±0.20)g/L],C4 [(0.70±0.1 1)g/L and (0.74±0.09)g/L],IgG [(1 9.65±3.02)g/L and (21.30±2.44)g/L],IgA [(5.64±1.25)g/L and (6.00 ±1.13)g/L]and IgM [(4.42±0.94)g/L and (4.83 ±0.77)g/L]in the moderate and high disease active groups were obviously higher (P <0.05).And the anti-CCP antibodies levels in the high disease active group were significantly higher than that in the moderate ones (P <0.05).The anti-CCP antibodies in RA patients had significant positive correlation with C3 ,C4 ,IgG,IgA and IgM (r=0.462,0.554,0.558,0.772,0.741,P <0.05).Conclusions:The levels of anti-CCP antibodies,C3 ,C4 ,IgG,IgA and IgM in RA patients were increased obviously,and they were correlated with the disease activity of RA.They could be important inde-xes for the diagnosis and illness monitoring of RA.%目的：：检测类风湿性关节炎(RA)患者血清抗环瓜氨酸肽(CCP)抗体、补体(C3、C4)及免疫球蛋白(IgG、IgA、IgM)水平,并探讨其临床意义.方法：将100例 RA 初治患者作为观察组,另选60例健康者作为对照组.根据 DAS28评分将 RA 患者分为高度活动组(25例)、中度活动组(30例)、低度活动组(24例)和缓解组(21例).分别测定 RA 患者和健康者血清抗 CCP 抗体、C3、C4、IgG、IgA 及 IgM 水平,比较 RA 患者与健康者以及不同病情活动的 RA 患者之间各血清指标水平差异,并分析抗 CCP 抗体与补体和免疫球蛋白的相关性.结果：(1)观察组抗 CCP 抗体[(67．75±21．28)U/mL]、C3[(1．95±1．14)g/L]、C4[(0．63±0．22)g/L]、IgG [(18．77±4．83)g/L]、IgA [(4．74±1．06)g/L]及 IgM [(4．02±0．98)g/L]水平显著高于对照组(P ＜0．05).(2)RA 活动期抗 CCP 抗体、C3、C4、IgG、IgA 及 IgM 水平显著高于缓解期(P ＜0．05)；其中,中、高度活动组抗 CCP 抗体[(73．83±5．28)U/mL、(86．50±6．39)U/mL]、C3[(2．24±0．18)、(2．35±0．20)g/L]、C4[(0．70±0．11)、(0．74±0．09)g/L]、IgG [(19．65±3．02)、(21．30±2．44)g/L]、IgA [(5．64±1．25)、(6．00±1．13)g/L]及 IgM [(4．42±0．94)、(4．83±0．77)g/L]水平均显著高于低度活动组(P ＜0．05)；高度活动组患者抗 CCP 抗体水平明显高于中度活动组(P ＜0．05).(3)RA 患者血清抗 CCP 抗体与 C3、C4、IgG、IgA、IgM 均呈显著正相关(r 分别为0．462、0．554、0．558、0．772、0．741,P 均＜0．05).结论：RA 患者血清中抗 CCP 抗体、补体及免疫球蛋白水平均升高,并与 RA 病情活动度有关,可作为 RA 早期诊断及病情监测的重要指标.
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