COPD 急性加重期合并 CHD 患者血浆 ET-1、IL-8的表达及意义

摘要

[ABSTRACT]Objective:To observe the expressions and clinical significance of plasma ET-1 and IL-8 in patients with AE-COPD merged with CHD.Methods:A total of 120 patients with AECOPD who were admitted in our hospital from February, 201 5 to December,201 5 were included in the study and divided into observation 1 group (AECOPD merged with CHD)and observation 2 group (pure AECOPD)with 60 cases in each group.Moreover,30 healthy individuals who came for physical ex-aminations in the same period were served as the control group.ELISA was used to detect the plasma ET-1 and IL-8 levels, and their correlation was analyzed.The arterial blood gas and coagulation fibrinolysis indicators among the three groups were compared.Results:The plasma ET-1 and IL-8 levels in observation 1 and 2 groups were significantly higher than those in the control group (P <0.05).The plasma ET-1 and IL-8 levels in observation 1 group were significantly higher than those in obser-vation 2 group (P <0.05 ).PaO 2 in observation 1 and 2 groups was significantly lower than that in the control group (P <0.05),while PaCO 2 was significantly higher than that in the control group (P <0.05).The comparison of PaO 2 and PaCO 2 be-tween the two groups was not statistically significant (P >0.05).PT and APTT in observation 1 and 2 groups were significant-ly shortened when compared with the control group (P <0.05),while TT was significantly delayed (P <0.05).PT in observa-tion 1 group was significantly shortened when compared with observation 2 group (P <0.05).Fbg and t-PA contents in obser-vation 1 and 2 groups were significantly higher than those in the control group (P <0.05).Fbg,t-PA,and D-D contents in ob-servation 1 group were significantly higher than those in observation 2 group (P <0.05 ).Conclusions:The hypercoagulation state is presenting in patients with AECOPD merged with CHD,with increased ET-1 and IL-8,both of which can play a syner-gistic effect,and are involved in the pathogenesis.%目的：：观察血浆内皮素-1(ET-1)、白细胞介素-8(IL-8)在慢性阻塞性肺疾病(COPD)急性加重期合并冠心病(CHD)患者血浆中的表达及临床意义.方法：选取我院2015年2月~2015年12月间收治的 COPD 急性加重期合并 CHD(观察1组)及单纯 COPD 急性加重期(观察2组)患者各60例，采用联免疫吸附试验(ELISA)测定血浆 ET-1及 IL-8水平，对二者间的相关进行分析，并对3组动脉血气及凝血纤溶指标进行比较；设立同期来院健康者30例进行对照观察.结果：观察1、2组患者血浆 ET-1、IL-8含量均明显高于对照组(P ＜0．05)；观察1组患者血浆 ET-1、IL-8含量明显高于观察2组(P ＜0．05)；观察1、2组患者 PaO 2明显低于对照组(P ＜0．05)；PaCO 2较明显高于对照组(P ＜0．05)；观察1、2组间 PaO 2、PaCO 2比较无统计学差异(P ＞0．05)；观察1、2组患者 PT、APTT 较对照组明显缩短， TT 明显延长(P ＜0．05)；观察1组 PT 明较观察2组明显缩短(P ＜0．05)；观察1、2组患者 Fbg、t-PA含量明显高于对照组(P ＜0．05)；观察1组 Fbg、t-PA 及 D-D 含量明显高于观察1组(P ＜0．05).结论：COPD 合并 CHD 患者体内呈高凝状态，且 ET-1、IL-8含量增高，二者起协同作用，共同参与发病.