Influence of tacrolimus combined mometasone furoate on serum inflammatory factors and immune function in children with eczema

摘要

Objective:To study the influence of tacrolimus combined mometasone furoate on serum inflammatory factors and immune function in children with eczema.Methods: A total of 122 children with eczema based on random data table method were divided into control group (n=58) and observation group (n=64) The control group were given 0.1％ mometasone furoate ointment treatment and the observation group of patients were given 0.03％ tacrolimus ointment treatment on the basis of the control group. After 3 weeks, the serum levels of inflammatory factors and index of immune function before and after treatment were compared. Results:Before the treatment, the levels of IL-2, IL-4, IL-5, INF-γ, CD3+, CD4+, CD8+, CD4+/CD8+ were similar in two groups, there was no statistically significant difference. Comparing the levels of inflammatory after treatment, IL-2, INF-γ levels of two groups were significantly higher than those of the same group before treatment, and IL-2, INF-γ levels of the observation group were significantly higher than those of the control group. After treatment, IL-4 IL-5 levels of the two groups were significantly declined and IL-4 IL-5 levels of the observation group were significantly lower than those of the control group. Immune function indicators level detection indicated that the levels of CD3+, CD4+, CD8+, CD4+/CD8+of control group before and after treatment had no significant change. After treatment, the levels of CD3+, CD4+ and CD4+/CD8+ of observation group were significantly increased and were significantly higher than those of the control group, whereas the levels of CD8+ were significantly reduced and significantly lower than those of the control group.Conclusions:Tacrolimus combined moetasone furoate is an effective therapy to adjust the serum levels of inflammatory cytokines and improve immune function of children eczema Indeed, it has a certain clinical value.