Objective To investigate the sleep status, quality of life, activities of daily living and the serum levels of interleukin-1β (IL-1β) and tumor necrosis factor alpha (TNF-α) in insomnia patients after meridian-collateral stroke treated by the new family rehabilitation program, a combined therapy including traditional family rehabilitalion, acupoint massage and ear point application. Methods A total of 80 cases of insomnia patients after meridian-collateral stroke were enrolled. Subjects were evenly divided into treatment group ( treated with new family rehabilitation program) and control group ( treated with traditional hospital health education and family rehabilitation). Clinical effects of the two groups were evaluated with the Pittsburgh Sleep Quality Index (PSQI), the brief version of WHO Quality of Life Assessment (WHOQOL-BREF) and activities of daily living ( ADL) . The serum levels of IL-1β and TNF-α were monitored before and after therapy and measured by enzyme-linked immunosorbent assay ( ELISA). Results ( 1) After treatment for 28 days, the scores of total PSQI, sleep time, sleep efficiency and sleep disorder incidence in the treatment group were significantly lower than those in the control group ( P<0.01) . ( 2) The scores of physiological, psychological, social relation, environmental dimensions of WHOQOL-BREF in the treatment group were significantly higher than those in the control group ( P<0.01) . ( 3) ADL scores were significantly higher in the treatment group than those in the control group (P<0.01) . (4) Serum levels of IL-1βand TNF-αwere increased in the treatment group as compared with those in the control group (P<0.01). Conclusion Compared with the traditional hospital health education, the new family rehabilitation program can effectively improve the quality of sleep, quality of life, as well as the activities of daily living. And the mechanism may be associated with the up-regulation of the serum levels of IL-1βand TNF-α, which are relevant to the sleep status.%【目的】调查新型家庭康复计划（家庭康复＋穴位按摩＋耳穴贴压）对中经络型中风病失眠患者睡眠质量、生存质量、日常生活能力及对血清白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）水平的影响。【方法】将80例中经络型中风病失眠患者随机分为采用新型家庭康复计划的治疗组和采用传统院内健康宣教家庭康复治疗的对照组各40例，采用匹兹堡睡眠质量量表（PSQI）、生存质量评定量表简表（WHOQOL-BREF）、日常生活能力（ADL）评估2组治疗的临床效果，并采用酶联免疫吸附法（ELISA）检测2组治疗前后血清中IL-1β、 TNF-α水平的变化情况。【结果】（1）治疗28 d后，治疗组PSQI总分、睡眠时间、睡眠效率及睡眠障碍等指标评分显著低于对照组（P<0.01）。（2）治疗组WHOQOL量表中生理、心理、社会关系、环境各维度得分显著高于对照组（P<0.01）。（3）治疗组ADL得分显著高于对照组（P<0.01）。（4）治疗组较对照组可显著提高中经络型中风病患者血清IL-1β、 TNF-α的水平（P<0.01）。【结论】与传统院内健康宣教治疗的对照组比较，新型家庭康复计划治疗组可更加有效地改善中经络型中风病失眠患者的睡眠质量、生存质量及日常生活能力，其机理可能与新型家庭康复治疗能更好地调节同睡眠相关的细胞因子IL-1β、 TNF-α水平有关。
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