宫颈癌患者肿瘤浸润性树突状细胞表达水平及其临床意义

摘要

目的:探讨肿瘤浸润性树突状细胞在宫颈癌组织中的表达水平及其临床意义.方法:前瞻性收集2015年1月至2017年1月山东青岛市立医院收治的宫颈癌患者84例,检测肿瘤组织及癌旁组织中肿瘤浸润性树突状细胞浸润情况,并分析其与宫颈癌患者临床特征的相关性.结果:与癌旁组织相比,宫颈癌组织中肿瘤浸润性树突状细胞密度、MHC-Ⅱ阳性百分比及CD54阳性百分比均显著降低(均P=0.000).与FIGO分期为Ⅰ期的患者相比,FIGO分期为Ⅱ期的患者宫颈癌组织中肿瘤浸润性树突状细胞密度、MHC-Ⅱ阳性百分比、CD54阳性百分比显著降低(均P=0.000).结论:宫颈癌组织中肿瘤浸润性树突状细胞低表达,且多为不成熟细胞,与预后不良有关.%Objective:To investigate the expression of tumor-infiltrating dendritic cells in cervical carcinoma and its clinical significance.Methods:From January 2015 to January 2017,84 cervical cancer patients treated in our hospital were enrolled.Tumor-infiltrating dendritic cells in tumor tissues were detected and the association with patients' clinical features was analyzed.Results:When compared with the adjacent tissues,tumor-infiltrating dendritic cells in the cervical carcinoma,MHC-Ⅱ positive percentage and CD54 positive percentage were decreased significantly (P=0.000).Patients with FIGO stage Ⅱ had lower tumor-infiltrating dendritic cells,MHC-Ⅱ positive percentage and CD54 positive percentage than those with FIGO stage Ⅰ (P=0.000).Conclusion:The expression of tumor-infiltrating dendritic cells was decreased in cervical cancer tissues,and most of them were immature cells.The low expression of tumor-infiltrating dendritic cells was related to poor prognosis of patients.