D-最优设计响应面法优选芪枣口服液提取工艺

摘要

Objective To optimize the extraction process of Qizao oral liquid. Method D-optimal response surface methodology was used. The key factors for extraction process, including water volume, decoction time and number of times were optimized by determining the content of Astragaloside IV. Result The optimal factors were as follows: 12 times volume of water, 1. 53 hours of decoction time for 3 times. Conclusion D-optimal response surface methodology could be successfully applied for the optimization of extraction process of Qizao oral liquid, which helps to enhance contents of active compounds and ensure the efficacy.%目的 采用D-最优设计响应面法优选芪枣口服液提取工艺.方法 以提取工艺中加水量、煎煮时间及煎煮次数等参数为自变量,进行D-最优设计;以黄芪甲苷总量为因变量,进行响应面分析.结果 优选芪枣口服液最佳提取工艺为:加水量12倍、煎煮时间1.53 h、煎煮次数3次.结论 D-最优设计响应面法能够优选芪枣口服液提取工艺,有利于提高有效成分含量和保证口服液疗效.