临床药师参与1例双碳青霉烯联合治疗泛耐药肺克血流感染的病例分析

摘要

目的 探讨泛耐药肺克的耐药机制及其引起血流感染的治疗措施.方法 临床药师通过1例入住ICU且只对多粘菌素敏感的泛耐药肺克血流感染患者,根据其基础状态调整抗感染治疗方案.结果 使用双碳青霉烯疗法治疗后,患者病情平稳,转出ICU.结论 双碳青霉烯治疗泛耐药肺克血流感染是作为无药可用情况下的挽救治疗方案,其有效性还需要大样本的实例来验证.%Objective To investigate the drug resistance mechanism of pan-resistant Klebsiella pneumoniae and the treatment measures on Klebsiella pneumoniae-caused bloodstream infection. Methods The clinical pharmacist adjusted the anti-infective treatment regimen on a pan-resistant Klebsiella pneumoniae infection patient in ICU,which was only susceptible to polymyxins.Results After treatment with double-carbapenem, the patient was in a stable condition and turned out of ICU. Conclusion Treatment of pan-resistant Klebsiella pneumoniae with double-carbapenem is a salvage regimen when short of available drug and its validity needs to be evaluated based on large sample data.