两亲性聚肽三嵌段共聚物的自组装行为

摘要

Poly（γ-benzyl-L-glutamate）-b-poly（ethylene glycol）-b-poly（γ-benzyl-L-glutamate）（PBLG-b-PEG-b-PBLG） triblock copolymer was synthesized via ring opening polymerization,and characterized by 1H-NMR and gel permeation chromatography（GPC）.GPC test shows that the polydispersity index（PDI） of the copolymer is very low.The self-assembled aggregates were prepared by dialysis method.The self-assembly behavior of the block copolymer in selective solvent（water） was investigated by transmission electron microscopy,scanning electron microscopy and laser light scattering.The experimental results show that the triblock copolymer can self-assemble into vesicles and micelles.The aggregate structures are found to be dependant on the initial solvent composition and mass concentration of polymers.%通过开环反应,合成了聚（L-谷氨酸-γ-苯甲酯）-b-聚乙二醇-b-聚（L-谷氨酸-γ-苯甲酯）（PBLG-b-PEG-b-PBLG）三嵌段聚肽共聚物。运用核磁共振氢谱和凝胶渗透色谱表征了聚合物的结构。凝胶渗透色谱测试表明合成的聚合物分子量分布窄。以选择性溶剂透析的方法制备了自组装聚集体,通过透射电子显微镜、扫描电子显微镜和激光光散射仪等表征了共聚物在水中的自组装行为。结果表明：该体系形成了以PBLG为内核,PEG为壳的囊泡和球形胶束;聚集体的结构依赖于起始溶液的溶剂性质和聚合物的质量浓度。