荧光/顺磁性双功能 CS/GdPO4∶Tb微球的制备及性质

摘要

A novel bifunctional bioinorganic composite combined with the interesting properties of paramagnet-ism,fluorescence was successfully prepared by encapsulation of GdPO 4 ∶Tb nanorods into the chitosan micro-sphere.The morphology and structure of the composite were characterized by X-ray diffraction (XRD),trans-mission electron microscope (TEM),scanning electron microscope (SEM),Fourier transform infrared spec-trometer (FT-IR).The results showed that the CS/GdPO 4 ∶Tb bifunctional microsphere owned nest-like shape and rough surface with an average diameter of 5 μm,which is different from the pure chitosan.The formation process was preliminary discussed.Additionally,the photoluminescence spectra and the paramagnetic properties revealed that the as-prepared bifunctional composites exhibited efficient luminescence and paramagnetism that had potential in magnetic resonance and optical imaging.Our results suggested that the obtained functionalized microspheres might be very attractive for biomedical applications.%用喷雾干燥法将 GdPO 4∶Tb 纳米棒包裹在壳聚糖(CS)微球中,成功地制备了一种新颖的 CS/GdPO 4∶ Tb 复合物微球。利用 X 射线衍射仪(XRD)、傅立叶红外光谱仪(FT-IR)、场发射扫描电子显微镜(SEM)、透射电镜(TEM)等检测手段表征了产物的形貌和结构特征。分析表明,CS/GdPO 4∶Tb 微球呈鸟巢状,表面粗糙,其粒径约为5μm,其形貌与相同条件下得到的纯壳聚糖微球显著不同,这主要是由于 GdPO 4∶Tb 纳米棒的骨架作用。磁性和荧光光谱的研究表明,该复合物同时具有良好的荧光性能和顺磁性,使其在生物医学领域具有潜在应用能力。