Cu＋／脯氨酸锂催化微波辅助合成苯并咪唑并喹喔啉衍生物的研究

摘要

Objective To synthesize Benzo[4 ,5]imidazo[l ,2-α]quinoxalines derivatives under mi-crowave irradiation in DMF . Methods A variety of N-(2-iodophenyl)-4-methylbenenesulfona-mides and 2-(chloromethyl)-1H-benzo [d]imidazoles could be reacted to give the desired corresponding products in high yields in 110 ℃ DMF for 30 min using copper/proline lithiumas catalysts under microwave irradia-tion . ResuIts We have developed an efficient protocol for synthesizing benzo [4 ,5]imidazo [l ,2-α]quinox-alines ;7 target compounds could be synthesized in good to excellent yields up to 94% ,and all of them were further characterized by 1 H NMR ,13C NMR and MS analysis . ConcIusion Synthesis of target benzo[4 ,5]imidazo[l ,2-α]quinoxalines compounds under microwave irradiation in water has an advantage of short reaction time and higher yields compared to the conventional method .%目的：用微波辐射催化法合成苯并咪唑并喹喔啉衍生物。方法在120 W微波辐射条件下，以碘化亚铜和脯氨酸锂为催化剂，N-对甲苯磺酰基-2-碘苯胺和2-氯甲基苯并咪唑在110℃二甲基甲酰胺中反应30 min得到苯并咪唑并喹喔啉及其衍生物。结果发现一种合成苯并咪唑并喹喔啉衍生物的新方法，获得7个相应的苯并咪唑并喹喔啉化合物，均已通过1 H NMR、13 C NMR和质谱确认结构，最高收率为94％。结论微波辐射法Cu＋／脯氨酸锂催化合成吡咯[1，2-α]喹喔啉，与传统方法比较，具有时间短、收率高的优点。