circRNA研究进展及其法医学应用展望

摘要

环状RNA(circular RNA,circRNA)是一类通过首尾相连形成的非编码RNA,在组织细胞中表达丰富,具有组织表达特异性的特点,并且具有较高的稳定性.最近的研究表明,circRNA在疾病及发生发展中具有调控功能,可能应用于临床疾病诊断以及帮助阐明疾病发病机制.本文对circRNA的生物学特性、分析研究方法以及作为分子生物学标记在临床应用中的研究进展进行综述,并对其在法医学领域中的应用进行展望.%Circular RNA(circRNA)is a type of noncoding RNA with tissue specificity and high stabil-ity, which forms a closed continuous loop and is abundantly expressed in tissue cells. According to re-cent research, the regulatory function of circRNA elucidating in the occurrence and development of dis-ease shows a potential for diagnosing clinical disease and revealing disease mechanism. This paper re-views the biological characteristics, analysis methods of circRNA and its research progress in clinical ap-plication as biomarker, and outlooks its application in the field of forensic medicine.