DAD1和AIF-1细胞因子在鱼类中的研究进展

摘要

Cytokines are some of low molecular weight proteins that serve as chemical messengers in the innate and adaptive immune systems of organisms.Defender against cell death 1 (DAD1) is likely to be involved in programmed cell death, which is an integral part of growth and development in multi-cellular organisms and is involved in response to a range of internal and external stimuli.Allograft inflammatory factor-1 (AIF-1) is an interferon (IFN)-Q-inducible Ca2+ binding protein.AIF-1 plays an important role in the survival and proinflammatory activity of macrophages and disintegrin.This paper reviews the advance in the research of functions and structures of DAD 1 and AIF- 1 and current research progress of the two cytokines in fish.We put forward the outlook with regard to innate immunity of fish and new direction in the future research of fish AIF-1 and DAD1.%细胞因子是一类由多种细胞合成或分泌的可溶性蛋白与多肽物质,具有调节多种细胞生理功能的作用.抗细胞凋亡因子(DAD1)是一种内源性细胞凋亡抑制基因.同种移植炎症因子(AIF-1)是一种由干扰素r诱导的钙离子结合蛋白.本文概述了DAD1和AIF-1的结构特点、功能表达、生物学作用及在水产动物中的最新研究进展,旨在为水产动物细胞因子的研究和有效应用提供参考资料.