胶原蛋白的化学改性方法及其应用的研究进展

摘要

Collagen is an important structural protein in animal body.It is widely used because of its biodegradability,biocompatibility and nontoxicity.In this paper,the research progress of the chemical modification of collagen by glutaraldehyde,β-cyclodextrin,polyrotaxane aldehyde,malonic acid and other crosslinking agents was reviewed,and the application of collagen modified materials in hemostatic,drug delivery carrier and tissue engineering scaffold was introduced.%胶原蛋白是动物体内重要的结构蛋白质,因具有生物可降解性、生物相容性、无毒等特性而被广泛应用.本文综述了戊二醛、β-环糊精聚轮烷单醛、丙二酸等交联剂对胶原蛋白进行化学改性的方法研究现状,并介绍了胶原蛋白改性材料在止血、药物运输载体、组织工程支架等方面应用的研究进展.