平均血小板容积、纤维蛋白原含量及血液流变学在青年脑梗死患者外周血中的变化

摘要

This study was aimed to explore the correlation of mean platelet volume (MPV), fibrinogen (FIB) and blood rheology with the youth patients with cerebral infarction, so as to provide the basis for the clinical early diagnosis and treatment. The 109 patients with cerebral infarction aged between 18 -45 were divided into three group: the largern( > 10 cm'), middle(4 - 10 cm3) and small ( < 4 cm3) area infarction; 30 healthy persons were served as control group. AU the four groups were subjected to 16 examinations, such as MPV, FIB, and rheology (Lηb,Mηb,Hηb, ηp, Lηr.Mηr.Hηr.KVE.EAI.ERI.EDI.EEI.HCT.ESR ). The results showed that all the MPV, FIB and rheology indexes of the different infarction groups were higher than those of healthy control group (P < 0.05). The MPV, FIB and rheology indexes in the large area infarction group were all higher than those in the small area infarction group( P < 0.05). The indexes of MPV, FIB and rheology in the various cerebral infarction area groups obviously decreased, but those did not reach to the level in the healthy control group( P < 0.05). The MPV, FIB content and rheology level correlated with infarction areas(r =0.36,0. 29 and 0.48, respectively). It is concluded that the serious intensity of youth patients with cerebral infarction positively correlated with the levels of MPV, FIB and rheology indexes. Regular examination of above mentioned index may be useful to prevent youth patients from cerebral infraction.%本研究旨在探讨平均血小板容积(MPV)、纤维蛋白原(FIB)含量及血液流变学改变与青年脑梗死患者梗死体积的相关性,为其临床早期诊断和治疗提供依据.根据头部CT或MRI病灶大小及神经功能受损程度将我院109例脑梗死患者(18 -45岁)分为大梗死组(梗死体积＞10 cm3)、中梗死组(梗死体积4-10cm3)、小梗死组(梗死体积＜4cm3),30例健康查体正常人作为对照组,进行MPV、FIB及血液流变学指标检查,包括:全血黏度低切(Lηb)、全血黏度中切(Mηb)、全血黏度高切(Hηb)、血浆黏度值(ηP)、全血还原黏度低切(Lηr)、全血还原黏度中切(Mηr)、全血还原黏度高切(Hηr)、血沉方程K值(KVE)、红细胞积聚指数(EAI)、红细胞刚性指数(ERI)、红细胞变形指数(EDI)、红细胞电泳指数(EEI)、红细胞比容、血沉,共计16项指标.结果表明:各组脑梗死患者MPV、FIB含量和血液流变学指标均高于健康对照组(P＜0.05)；大梗死组MPV、FIB含量和血液流变学指标均高于小梗死组(P＜0.05)；各组脑梗死患者在病程恢复期MPV、FIB含量和血液流变学指标均有明显下降,但未达到健康对照组水平(P＜0.05).脑梗死体积与MPV、FIB含量及血液流变学水平呈正相关(r=0.36,0.29,0.48).结论:青年脑梗死病情的严重程度与MPV、FIB及血液流变学水平密切相关,定期检查上述指标对预防青年脑梗死很有价值.