表皮生长因子受体通路底物8(Eps8)是表皮生长因子受体重要的激酶活性底物之一.在生理功能上,Eps8与细胞的有丝分裂、分化有关.近年来发现,Eps8参与了多种恶性实体瘤的增殖、转移,并与预后相关.有研究表明,Eps8主要通过形成Eps8-Abi1-Sos1三聚体参与Ras-Rac途径或通过rab5介导的EGFR内化途径来调节肿瘤增殖、转移,并能参与细胞周期的调节,因此有望成为恶性肿瘤监测与治疗的新靶点.本文对Eps8的分子结构和生理功能作简要介绍,重点对Eps8在不同恶性肿瘤中与增殖、转移和预后的关系及相关分子机制研究现状作一综述.%Epidermal growth factor receptor pathway substrate 8 ( Eps8) is one of crucial kinase substrates for the epidermal growth factor receptors. Eps8 is related to mitosis and differentiation of normal cells. In recent years, it has been demonstrated that Eps8 involves in proliferation, metastasis and prognosis of many malignant tumors. Experiments have shown that Eps8 involves in Ras-Rac pathway of EGFR signaling by forming Eps8-Abil-Sosl tri-complex or participates in endocytosis mediated by rab5. Furthermore, Eps8 has also been found to regulate cell cycle. In conclusion, it may become a monitor and a new target for the treatment of malignant tumors. This review briefly introduces molecular structure and physiological function of Eps8, focusing on its function and molecular mechanism in proliferation, metastasis and prognosis of malignant tumors.
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