Objective:To observe the efficacy of chemotherapy consisted of bortezomib as main druy in maintenance therapy for recurrence of newly diagnosed MM patients.Methods:The clinical data and outcome of 37 MM patients during 2008-2013 were analyzed retrospectively,the 37 MM patients were divided into 2 group:19 cases including 13 cases of newly diagnosed MM with symptoms and 6 cases of relapsed refractory MM were enrolled in group A;17 cases of newly diagnosed MM with symptoms were enrolled in group B.The patients of group A received maintenance therapy consisted of bortezomib plus dexamethasone (VD group),while the patient group B received maintenance therapy consisted of melphalan plus prednisone (MP group),then the therapeutic efficacy of 2 group was compared.Results:The overall response rate(ORR) in VD groupe was 84.2％ (16/19),out of which CR rate reached 42％ (8/19),PR rate reached 31.6％ (6/19),MR rate reached 10.5％ (3/19).During median follow-up for 21.8 (5-51) months,death occurred,while the ORR in MP group was 52 (9/17),out of which CR rate was 23.5 ％ (4/17),PR rate reached 23.5 ％ (4/17),MR rate reached 5.9％ (1/17).Druing median follow-up for 16.4 (4-39) months,the worteity reaced 64.7％ (11/17).The differencr between 2 groups was significant(P ≤ 0.05).The median OS time of patients in VD group was 21.6 months,that in MP group was 17.9 months(P ≤0.05).The median PFS in VD group and MP group were 13.4 and 9.4 months respectively(P ≤0.001).Conclusion:The ORR and CR rates of bortezomib maintenance therapy for newly diagnosed and relapsed / refractory MM patients are very high,and its toxicity can be controlled,therefore,the patients need maintenance therapy after remission.%目的:观察以硼替佐米或马法兰为主的化疗方案,在初诊有症状的MM或MP治疗后复发难治性的多发性骨髓瘤(MM)患者维持治疗中的疗效.方法:对本院2008-2013年5年期间MM患者的临床经过及转归进行了回顾性分析.19例初诊有症状的MM(13例),复发难治性的MM患者(6例),以硼替佐米(bortezomib)+地塞米松(Dexamethasone)治疗后进行维持治疗的VD组,17例(初诊有症状的MM),接受马法兰+泼尼松治疗后再进行维持治疗的为MP组,比较两组的疗效.结果:可评估的36例患者,中位随访时间16(1-64)个月,两组患者半年复发率比较差异有统计学意义,VD组19例中半年无1例复发,MP组17例中半年有5例复发(P≤0.05).结论:VD作为MM患者维持治疗的方案优于MP方案,而且毒副作用小.
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