骨髓涂片及骨髓活检切片同步分析在淋巴瘤诊断中的意义

摘要

目的:探讨骨髓涂片及骨髓活检切片同步分析在淋巴瘤诊断中的临床意义.方法:对本院50例初诊淋巴瘤患者采取骨髓涂片及活检双标本一次同步取材,同步分析两者的观察结果.结果:骨髓活检切片对骨髓增生程度的判断优于骨髓涂片,活检切片显示增生程度均为活跃及以上;50例淋巴瘤患者中12例(24％)中骨髓涂片中可见淋巴瘤细胞,骨髓活检切片淋巴瘤细胞检出率为44％(22例),差异具有统计学意义.淋巴瘤骨髓侵犯患者骨髓活检切片中均可见网状纤维组织增生,以轻、中度为主,骨髓纤维化程度与骨髓淋巴瘤细胞数量呈一定的正相关性.结论:骨髓涂片联合骨髓活检切片同步分析能提高淋巴瘤骨髓侵犯的诊断准确率.%Objective:To explore the value of bone marrow smear combined with biopsy in the diagnosis of lymphoma.Methods:Clinical data of 50 cases of lymphoma from our hospital were analyzed retrospectively,and the results of the bone marrow smear and the bone marrow biopsy were compared simultaneously.Results:The decision for the degree of bone marrow hyperplasia in bone marrow biopsy slice was superior to that in smear,and the active or highly active hyperplasia of nucleated cells were observed in all the bone marrow biopsies;the lymphomatic cells were observed in bone marrow smear of the 12 patients (24％),but the bone marrow biopsies showed a higher detection rate of lymphomatic cells 44％ in 22 patients (P ＜ 0.05);The hyperplasia of bone marrow fibrous tissue,mainly mild to moderate,were the common in cases with bone marrow involvement and the severity of bone marrow fibrosis positively correlated with the number of lymphomatic cells.Conclusion:Biopsy combined with aspiration can improve the accuracy of diagnosis in lymphoma with bone marrow involvement.