输注两种不同红细胞对自身免疫性溶血性贫血患者实验室指标及疗效影响的对比

摘要

目的:探究输注2种不同红细胞对自身免疫性溶血性贫血(AIHA)患者实验室指标及疗效的影响.方法:采用回顾性探究的方法,选取2015年6月至2016年6月本院收治的自身免疫性溶血性贫血患者120例,其中60例患者输血治疗采用输注洗涤红细胞治疗,为甲组;另60例患者输血治疗采用输注去白红细胞治疗,为乙组.查询并记录比较甲组和乙组患者输血治疗前和输血后24 h的实验室指标变化情况,对比2组患者的疗效、症状改善情况和不良反应发生情况.结果:2组患者治疗ld后的RBC、Hb水平较输血治疗前非常显著升高(P＜0.01),TBIL、Ret水平较输血治疗前非常显著降低(P＜0.001).2组患者治疗前及治疗后的RBC、Hb、TBIL、Ret水平,治疗后乏力、头晕、气短、心悸等贫血症状改善情况,治疗后综合疗效,不良反应发生率等的差异均无统计学意义(P＞0.05).结论:去白红细胞及洗涤红细胞均能在短时间内明显缓解AIHA患者的贫血情况.%Objective:To investigate the effect of 2 kinds of red blood cells (RBC) on the laboratorial indexes and therapeutic efficacy of patients with autoimmune hemolytic anemia (AIHA).Methods:The clinical data of 120 patients with AIHA from June 2015 to June 2016 were analyzed retrospectively.These 120 patients were divided into A goup and B group.The patients in A group (60 cases) were infused with washed RBC,while the patients in B group (60 cases) were infused with WBC-deplated RBC.The changes of laboratotial indexes,clinical symptoms and incidence of adverse reactions in 2 groups before treatment and at 24 hourse after treatment as well as the therapeutic efficacy and improvement status of clinical symptoms were compared.Results:The RBC count and Hb level in 2 groups after treating for 1 day were significantly higher than those before treatment (P ＜ 0.01),while the TBIL level and reticulocyte (Ret) count were significantly lower than those before treatment (P ＜ 0.01).However,the RBC,Hb,TBIL levels and Ret count in 2 groups before and after treatment showed no statistical difference (P ＞ 0.05);the improvement of clinical symptoms,complex therapeutic efficacy and incidence of adverse reactions in 2 groups after treatment also showed no significantly difference (P ＞ 0.05).Conclusion:Both washed and leukocyte-deplated RBC can alleviate the anemia in patients with AIHA in short-time,but the leucocyte-deplated RBC is more expensive,suggesting that the wased RBC is more practical for treatment of AIHA patients.