血液肿瘤患者合并细菌感染时中性粒细胞CD64的变化

摘要

目的:探究血液肿瘤患者合并细菌感染时中性粒细胞表面CD64的变化.方法:选择2014年8月至2016年2月在我院就诊收治的血液肿瘤患者97例,作为此次临床研究的对象.根据患者的症状和体征以及微生物血培养检测结果,将患者分成血液肿瘤感染组(50例)和血液肿瘤非感染组(47例).采用流式细胞术检测患者中性粒细胞表面CD64指数、血清C-反应蛋白(CRP)、中性粒细胞计数(NC)和降钙素原(PCT)水平.感染组患者接受治疗后,再次检测CD64、CRP、PCT以及NC水平.结果:未接受治疗时,感染组患者CD64指数明显高于非感染组,CRP、PCT和NC水平也高于非感染组;对感染组进行针对性的抗细菌感染治疗后,感染组CD64指数、CRP、PCT和NC水平均有所下降.结论:血液肿瘤患者合并细菌感染时CD64指数明显升高,治疗后有所降低,此结果肯定了CD64在诊断血液肿瘤患者细菌感染方面的价值.%Objective:To explore the changes of CD64 on surface of neutrophils in patients with hematological malignancies combined with bacterial infections.Methods:Ninety-seven patients with hematological tumor admitted in our hospital from August 2014 to February 2016 were selected and divided into 2 groups:infection group(50 cases) and noninfection group (47 cases) according to their symptoms,physical sings and blood culture results for microbiologic detection.The CD46 index on surface of neutrophils,serum C-reactive protein (CRP),neutrophil count (NC) and procalcitonin (PCT) level were detected by flow cytometry.After treatment of infection patients,the CD46 index,CRP,PCT and NC were detected again.Results:Before antibacterial treatment of patients,the CD64 index in infection group was significantly higher than that in noninfection group,the CRP,PCT and NC levels in infection group also were higher than those in noninfection group;after antibacterial treatment,the CD64 index,CRP,PCT and NC levels in infection group decresed.Conclusion:The CD64 index in hematologic malignancy patients complicated with bacterial infections significantly increased,after antibacterial treatment these indexes decreases,confirming the value of CD64 in the diagnosis of bacterial infections for patients with hematologic malignancies.