炎症相关因子基因多态性与弥漫大B细胞淋巴瘤的易感性研究

摘要

Objective:To investigate the relationship of gene polymorphisms of inflammattion related cytokines with incidence of diffuse large B-cell lymphoma (DLBCL) in Gansu Han population.Methods:The gene polymorphism of inflammation-related cytokines were detected by high-resolution melting (HRM) curve.Results:The homozygous CC genotype carrying IL-1RA rs4251961 gene locus was related with the risk of DLBCL in comparison with homozygous TT,the OR was 0.83 of homozygous CC,95 ％ CI =0.697-0.997,P ＜ 0.05),while the C allele of IL-1RA rs4251961 gene locus significantly correlated with the high incidence of diffuse large B-cell lymphoma compared with T allele(OR =8.83,95％ CI =1.909-40.813,P ＜ 0.01).Conclusion:The minor allele C of IL-1RA rs4251961 gene locus significantly relates with the susceptibility to DLBCL.%目的:探讨甘肃汉族人群中炎症相关因子基因多态性与弥漫大B淋巴瘤(diffuse large B-cell lymphoma,DLBCL)发病率的相关性.方法:运用高分辨率溶解曲线(high-resolution melting,HRM)方法检测炎症因子基因多态性.结果:IL-1RA的rs4251961位点CC纯合子基因型携带者与患DLBCL风险有关(以TT为参照,CC基因型的OR为0.83,95％CI=0.697-0.997,P＜0.05),但与T等位基因相比,C等位基因与DLBCL风险升高显著相关(OR=8.83,95％ CI=1.909-40.813,P＜0.01).结论:IL-1RA的rs4251961位点的次等位基因C与DLBCL的易患性显著相关.