硫辛酸注射液联合二甲双胍缓释片对糖尿病周围神经病患者 NCV 及氧化应激反应的影响

摘要

Objective:To study the effect of nerve conduction velocity and oxidative stress of DL‐Thioctic acid combined with metformin in treatment of patients with diabetic peripheral neuropathy (DPN) .Methods:110 patients with DPN were divided into the observation group (55 cases) and the con‐trol group .While conventional blood sugar was controlled ,the control group received metformin treat‐ment ,observation group was treated with DL‐Thioctic acid combined with metformin .clinical symptoms , nerve conduction velocity (NCV) ,oxidative stress reaction were compared between two groups .Results:Curative effect :The effective rate of the observation group(96% ) was significantly higher than the con‐trol group (85% ,χ2 = 3 .960 , P <0 .05);Clinical symptoms :In the observation group lower limb and foot pain ,paresthesia ,burning score were significantly lower than in the control group(t= 3 .245 ~5 .638 ,P<0 .05);About NCV ,median nerves ,Phil and nervous motor conduction velocity(MCV) and sensory conduction velocity(SCV) in the observation group were significantly higher than in the control group (t=4 .126~7 .325 ,P<0 .05);Oxidative stress response:In the observation group ,serum malond‐ialdehyde (MDA) and creactive protein (CRP) were significantly lower superoxide dismutase (SOD) was significantly higher than in the control group(t=7 .365~12 .106 , P< 0 .05) .Conclusion:DL‐Thioctic acid combined with metformin can help to relieve patients’ clinical symptoms ,promote the recovery of SCV and MCV ,reduce oxidative stress reaction and improve therapy effect .%目的：观察硫辛酸注射液联合二甲双胍缓释片对糖尿病周围神经病（DPN ）患者神经传导速度（NCV）及氧化应激反应的影响。方法：选择2013年4月～2015年4月收治的110例DPN患者为研究对象，采用随机数字表法分为观察组和对照组各55例。在常规控制血糖的同时，对照组给予二甲双胍缓释片治疗，观察组采用硫辛酸注射液联合二甲双胍缓释片治疗，比较两组临床症状改善情况、NCV变化。结果：治疗效果：观察组总有效率96％明显高于对照组85％（χ2＝3．960，P＜0．05）；临床症状：观察组下肢与足部疼痛、感觉异常、灼热感评分明显低于对照组（ t＝3．245～5．638， P＜0．05）；NCV ：观察组正中神经、腓总神经MCV、SCV均明显快于对照组（t＝4．126～7．325， P＜0．05）。结论：硫辛酸注射液联合二甲双胍缓释片能有助于缓解患者的临床症状，促进MCV和SCV的恢复，减轻氧化应激反应，提高治疗效果。