自拟补气滋阴方联合强化胰岛素方案治疗糖尿病酮症酸中毒临床研究

摘要

Objective:To observe the clinical effect of Buqi Ziyin Decoction and intensive insulin on diabetic ketoacidosis.Methods:100 patients with diabetic ketoacidosis were randomly divided into the control group and the treatment group,50 cases in each.The control group was treated with intensive insulin;the treatment group added Buqi Ziyin Decoction.Results:The total effective rate of the treatment group was 94.00％,and that of the control group was 74.00％;the difference between the two groups was statistically significant (P＜ 0.05).Blood glucose recovery time,the time of urinary ketone disappearance and the disappearance time of acidosis in the treatment group were significantly shorter than those in the contrcl group (P＜ 0.05).The scores of TCM syndromes in the two groups were significantly better than those before treatment(P＜0.05);the scores of TCM syndromes in the treatment group were significantly better than those in the control group(P＜ 0.05).The blood glucose levels of the two groups after treatment were significantly lower than those before treatment (P＜ 0.05).Compared with the control group,the treatment group improved more significantly(P＜ 0.05).The serum ion index and renal function index of the two groups after treatment were significantly better than those before treatment (P ＜ 0.05);the treatment group was better than the control group (P＜ 0.05).Conclusion:Buqi Ziyin Decoction combined with intensive insulin on diabetic ketoacidosis can significantly reduce the clinical symptoms and signs,speed up the rehabilitation process,regulate blood sugar and serum levels of ions,and help improve kidney function.%目的 观察自拟补气滋阴方联合强化胰岛素方案治疗糖尿病酮症酸中毒临床效果并探讨其机制.方法 将100例糖尿病酮症酸中毒患者按随机数字表法分为对照组和治疗组,各50例.对照组采用强化胰岛素方案,治疗组在此基础上加用自拟补气滋阴方辅助治疗.结果 治疗组总有效率为94.00％,明显高于对照组的74.00％(P＜ 0.05);观察组患者血糖复常时间、尿酮消失时间及酸中毒消失时间均显著短于对照组(P＜0.05);两组治疗后中医证候积分均显著优于治疗前(P＜0.05);两组比较,治疗组患者治疗后中医证候积分显著优于对照组(P＜0.05).两组患者治疗后血糖指标水平均显著低于治疗前(P＜0.05);两组比较,治疗组较对照组改善更加显著(P＜0.05).两组治疗后血清离子指标和肾功能指标水平均显著优于治疗前(JP＜0.05);治疗组患者均显著优于对照组(P＜0.05).结论 自拟补气滋阴方联合强化抗胰岛索方案治疗糖尿病酮症酸中毒可显著减轻临床症状体征,加快病情康复进程,调节血糖和血清离子水平,并有助于改善肾脏功能.