养血益肾方对肾性贫血患者微炎症状态的影响和疗效观察

摘要

Objective:To observe the clinical effect of Yangxue Yishen decoction on patients with renal anemia.Methods:106 cases of patients with renal anemnia were randomly divided into erythropoietin group (group E),Yangxue Yishen decoction group (group Y) and intensive group (group E +Y),which were given erythropoietin essence,Yangxue Yishen decoction,Yangxue Yishen decoction and erythropoietin for 8 weeks.Curative effect,Serum creatinine (Scr),interleukin-6 (IL-6),hemoglobin (HGB),hematocrit (Hct) in each group was compared before and after the treatment.Results:The curative effect of group E,group Y and group E+Y was better after the treatment (P＜ 0.05 or P ＜ 0.01),and the curative effect of group E+Y was better than group E and group Y (P ＜ 0.01 or P＜ 0.05),while the curative effect of group E and group Y was not different (P＞ 0.05).The improvement of Scr,IL-6,HGB and Hct of group E,group Y and group E+Y was better after the treatment (all P＜0.01),and the improvement of Scr,IL-6,HGB and Hct of group E+Y was better than group E and group Y (all P＜ 0.01),and there was no difference on improvement of IL-6,HGB and Hct between group E and group Y (allP＞0.05) while the improvement of Scr in group Y was better than that of group E (P＜0.05).Conclusion:Yangxue Yishen decoction can correct anemia and improve kidney function in patients with renal anemia,which may be related to its effect on scavenging IL-6.%目的 观察养血益肾方治疗肾性贫血患者的临床疗效.方法 106例患者随机分为促红素组38例、养血益肾组39例和强化组(促红素+养血益肾方)39例,分别给予促红素、养血益肾方和促红素+养血益肾方治疗8周,比较各组的疗效及血肌酐(Scr)、白介素-6(IL-6)、血红蛋白(HGB)、红细胞压积(Hct)的变化.结果 强化组总有效率为92.31％,明显优于促红素组的78.95％和养血益肾组的69.23％(P＜0.05或P＜0.01),而促红素组和养血益肾组比较差别不大(P＞0.05).各组治疗后对Scr、IL-6、HGB和Hct的改善均优于治疗前(均P＜0.01);强化组Scr、IL-6、HGB和Hct的改善均优于促红素组和养血益肾组(均P＜0.05),促红素组和养血益肾组IL-6、HGB和Hct改善比较差异无统计学意义(均P＞0.05),而养血益肾组Scr改善优于促红素组(P＜0.05).结论 养血益肾方对于肾性贫血患者具有纠正贫血、改善肾功能的作用,可能与其清除IL-6有关.