Correlation of serum vitamin C content with renal anemia,oxidative stress and microinflammatory state in patients with peritoneal dialysis

摘要

Objective: To study the correlation of serum vitamin C content with renal anemia, oxidative stress and microinflammatory state in patients with peritoneal dialysis. Methods: A total of 96 patients undergoing peritoneal dialysis in the First Affiliated Hospital of Soochow University between January 2016 and January 2017 were selected as the peritoneal dialysis group, and 50 healthy volunteers receiving physical examination in the First Affiliated Hospital of Soochow University during the same period were selected as the normal control group. The contents of VitC as well as renal anemia, oxidative stress and microinflammation-related indexes in peripheral blood of two groups of subjects were detected, and Pearson test was used to evaluate the correlation of serum VitC content with renal anemia, oxidative stress and microinflammatory state in patients with peritoneal dialysis. Results: VitC content in peripheral blood of peritoneal dialysis group was lower than that of normal control group;renal anemia-related indexes Hb, RBC and TIBC levels in peripheral blood were lower than those of normal control group; oxidative stress indexes LHP, MPO and AOPPs contents in serum were higher than those of control group while SOD and GSH-Px contents were lower than those of control group; inflammatory factors CRP, IL-6, IL-8, IL-10 and IL-13 contents in serum were higher than those of normal control group. VitC content in serum of patients with peritoneal dialysis was positively correlated with Hb, RBC, TIBC, SOD and GSH-Px levels, and negatively correlated with LHP, MPO, AOPPs, CRP, IL-6, IL-8, IL-10 and IL-13 contents. Conclusion: Serum VitC content is lower in patients with peritoneal dialysis, and the specific content is directly correlated with the severity of renal anemia, oxidative stress and microinflammatory state.