依据中医“肺与大肠相表里”采用中西医结合治疗重症肺炎患儿疗效观察

摘要

目的 观察根据中医“肺与大肠相表里”理论应用双歧杆菌三联活菌胶囊联合清热化瘀散治疗重症肺炎患儿并防治胃肠功能障碍的疗效及安全性.方法 选取120例重症肺炎患儿作为研究对象,并随机分为观察组和对照组各60例.对照组患儿采用常规重症肺炎治疗,观察组在对照组患儿的基础上加用双歧杆菌三联活菌胶囊联合清热化瘀散进行治疗.观察比较两组患儿治疗前后肺炎疗效情况、血浆D-乳酸含量和二胺氧化酶(DAO)含量变化情况、胃肠功能障碍发生情况、平均住院时间情况,以评价根据“肺与大肠相表里”理论应用双歧杆菌三联活菌胶囊联合清热化瘀散防治肺炎患儿并发胃肠功能障碍的疗效及安全性.结果 观察组患儿共58例(96.67％)完成研究,对照组患儿共55例(91.67％)完成研究;观察组患儿肺炎疗效明显由于对照组,其差异有统计学意义(P＜ 0.05);重复测量资料的方差分析显示,观察组患儿血浆D-乳酸水平和DAO活性变化情况均明显优于对照组患儿,其差异有统计学意义(P＜ 0.05);观察组患儿胃肠功能障碍发生率为5.17％,明显低于对照组的18.18％,其差异有统计学意义(P＜0.05);观察组患儿平均治愈时间为(9.55±4.28)d,明显短于对照组患儿的(13.34±6.85)d,其差异有统计学意义(P＜0.01).结论 依据“肺与大肠相表里”理论采用双歧杆菌三联活菌胶囊联合清热化瘀散对重症肺炎患儿进行治疗可以显著提高疗效,降低患儿D-乳酸、和DAO水平,降低患儿胃肠功能障碍发生率,缩短患儿治愈时间.%Objective:To evaluate the efficacy and safety of Live Combined Bifidobacterium,Lactobacillus and Enterococcus capsules associated with Qingre Huayu San in the treatment of children with severe pneumonia and controlling gastrointestinal dysfunction based on Traditional Chinese Medicine (TCM) theory of lung and large intestine being interior-exteriorly related.Methods:120 cases of children who were diagnosed with severe pneumonia were randomly divided into the experimental group(n =60) and the control group(n =60).Both groups received conventional treatment while the experimental group also received the live combined Bifidobacterium,Lactobacillus and Enterococcus capsules combined with Qingre Huayu San.The aspects below were examined as criteria:treatment effect,content of plasma D-lactic acid and the activity of Diamine oxidase (DAO),incidence of gastrointestinal dysfunction,and the average length of hospital stay.Results:The experimental group had 58 cases(96.67％) that finished the follow-up while the control group got a total of 55 cases(91.67％).The curative effect of the experimental group was significantly higher than that of the control group(P＜ 0.05).The variance analysis showed the experimental group presented more plasma D-lactic acid (P＜ 0.05),better DAO activity (P＜0.05);less incidence of gastrointestinal dysfunction (P ＜ 0.05) and shorter average length of hospital stay (P ＜0.01).Conclusion:The results indicate that using Live Combined Bifidobacterium,Lactobacillus and Enterococcus capsules associated with Qingre Huayu San in the treatment of children with severe pneumonia based on TCM theory of lung and large intestine being interior-exteriorly related is effective and safe.Treated with Live Combined Bifidobacterium,Lactobacillus and Enterococcus capsules associated with Qingre Huayu San,the plasma Dlactic acid and activity of DAO are increased while the incidence of gastrointestinal dysfunction and the average length of hospital stay are decreased.