Objective To explore the relation between serum Tenascin-C (TN-C) and coronary artery lesion in children with Kawasaki disease (KD). Methods Serum TN-C was measured and coronary artery was evaluated by echocardiography in children with KD treated during January 2013 and December 2016 and compared to that of healthy children. Results A total of 252 KD children (160 male, 92 female, aged from 3 to 80 months) and 50 healthy children (32 male, 18 female, aged from 4 to 80 months) were enrolled. Serum TN-C level was significantly higher in KD children[76.8 (34.3, 660.7) ng/ml] than in healthy children[22.9 (14.6, 77.8) ng/ml] (U=6.358, P＜0.01), and significantly higher in KD children with than without coronary artery lesion [142.5 (59.7, 660.7) ng/ml vs. 70.3 (34.3, 271.1) ng/ml]. Logistic multivariate regression showed that male, C-reactive protein, the time from onset to intravenous immunoglobulin (IVIG) injection＞10 d, IVIG resistance and TN-C were independent risk factors for coronary artery lesion.Conclusion Increased serum TN-C may be an independent risk factor for the occurrence of coronary artery lesion in KD children.%目的 探讨川崎病患儿血清腱糖蛋白C(TN-C)水平与冠状动脉病变的关系.方法 对2013年1月至2016年12月就诊的川崎病患儿行血清TN-C水平测定及冠状动脉超声心动图检测,并与健康婴幼儿比较.结果 川崎病患儿252例,男160例,女92例,年龄3～80(24±8)个月,健康婴幼儿50例,男32例,女18例,年龄4～80(26±7)个月.川崎病患儿血清TN-C水平[76.8(34.3,660.7)ng/ml]显著高于健康婴幼儿[22.9(14.6,77.8)ng/ml],差异有统计学意义(U=6.358,P＜0.01).川崎病患儿中,有冠状动脉病变者血清TN-C水平显著高于无冠状动脉病变者[142.5(59.7,660.7)ng/ml vs.70.3(34.3,271.1)ng/ml].logistic多元回归显示男性、C-反应蛋白升高、应用静脉注射免疫球蛋白(IVIG)时发病时间＞10d、IVIG抵抗和TN-C升高为冠状动脉病变发生的独立危险因素.结论 川崎病患儿TN-C血清水平升高是发生冠状动脉病变的独立危险因素.
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