Objective To explore the correlation of serum T3 level with N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with chronic heart failure (CHF). Methods Serum T3 and plasma NT-proBNP were measured in 97 patients with CHF. They were divided into low T3 group (n=45) and normal T3 group (n=52). Plasma NT-proBNP and the prognosis of heart failure were compared between the two groups. Results Low T3 group had significantly higher plas-ma NT-proBNP than normal T3 group in al patients [(1 775.40±543.78)pg / ml vs. (1 205.96±336.59)pg / ml] and in pa-tients stratified by NYHA class [(643.07±249.32)、(1 392.75±412.63)、(3 178.66±727.13)pg / ml] vs. [(405.17±227.35)、(947.48±317.22)、(2 057.13±436.10)pg / ml] (P<0.05). The incidence of adverse events was higher in low T3 group than in normal T3 group (53% vs.25%). Conclusion Serum T3 level may be used as a non- specific prognostic indicator of chronic heart failure.% 目的探讨慢性充血性心力衰竭患者血清三碘甲状腺原氨酸(T3)与血浆 N 末端脑钠肽原(NT-proBNP)的关系.方法测定97例慢性充血性心力衰竭患者血清 T3与血浆 NT-proBNP 水平，比较低 T3组(n=45)和正常 T3组(n=52)的NT-proBNP 水平，并观察预后.结果低 T3组 NT-proBNP 水平[(1775.40±543.78)pg / ml]较正常 T3组[(1205.96±336.59)pg / ml]增高，差异有统计学意义(P<0.05).在同级别的心力衰竭患者中，低 T3组血浆 NT-proBNP 水平[(643.07±249.32)、(1392.75±412.63)、(3178.66±727.13)pg / ml]均显著高于正常 T3组[(405.17±227.35)、(947.48±317.22)、(2057.13±436.10)pg / ml](均 P<0.05).低 T3组不良事件发生率(53%)较正常 T3组(25%)增高，差异有统计学意义(P<0.05).结论血清 T3可以作为慢性心力衰竭患者观察病情、判断预后的非特异性指标.
展开▼
