Objective To explore the impact of Anti-SSB antibody positive or negative on clinical manifestation, laboratory index , treatment and thera-peutic effect in SLE patients, thus to offer clues to how the condition develops. Methods Using retrospective approach to analyze the differences of clinical manifestation, laboratory index, treatment and therapeutic effect in 100 SLE patients according to gender and age with anti-SSB positive or anti-SSB nega-tive. Results The major SLE patients were childbearing age women, the average age was 28. 6 years and 88% were Han nationality. Compared with those whose anti-SSB bodies were negative , the SLE patients whose anti-SSB bodies were positive had a higher rate of malar erythema, anti-ds-DNA positive and neutropenia . Conclusion The incidence of malar erythema, anti-ds-DNA positive and neutropenia in SLE patients whose anti-SSB antibody was posi-tive is higher than negative.%目的：分析探讨系统性红斑狼疮( Systemic Lupus Erythematosus ,SLE)患者抗SSB抗体阳性和SSB抗体阴性对临床表现、实验室指标、治疗及疗效的影响,为更深入研究疾病的发展提供线索。方法采用回顾性调查方法,按不同性别、年龄[育龄期(15~49)岁,育龄期后≥50岁]分析l00名抗SSB抗体阳性及阴性的系统性红斑狼疮患者的临床表现、实验室检查、治疗及疗效的关系。结果 SLE患者中以育龄期女性为多,平均年龄28.6岁。汉族占88%。抗SSB抗体阳性的SLE患者蝶形红斑、抗ds-DNA抗体(+)、外周血中性粒细胞减少的比率明显高于抗SSB抗体阴性的SLE患者。结论抗SSB抗体阳性的SLE患者发生面部蝶形红斑、外周血中性粒细胞减少及抗ds-DNA抗体阳性的机率高于抗SSB抗体阴性的的患者。
展开▼
