胃食管反流源性哮喘发病机制的研究现状

摘要

Gastroesophageal reflux disease and asthma are very common diseases .Nearly 50 percent to 80 percent of asth-matics show a close relationship with gastroesophageal reflux disease .The article gives a brief introduction about gastroe-sophageal reflux disease and provides four mechanisms including acid micro -aspiration induced asthma , the use of bron-chodilators promotes the further development of asthma , reflux causes lung reflex and then induces broncho -constriction of asthma, and hyperresponsiveness after reflux infiltrate airway .The purpose of this article is to guide the doctors'clinical treatment of gastroesophageal reflux disease -induced asthma .%胃食管反流病与哮喘都是十分常见的疾病。哮喘患者中有50％～80％与胃食管反流病相关。本文介绍胃食管反流病并从四个方面具体分析了反流促发哮喘的机制，其中包括反流物被吸进肺内引起哮喘、使用支气管扩张药引起反流加重进而促进哮喘的进一步发展、反流物引发神经反射造成肺支气管收缩从而引发哮喘和反流物浸入气道使其处于高反应状态。通过分析本病的具体机制可以在一定基础上指导临床医生在实际工作中对胃食管反流源性哮喘的治疗。