目的 应用二维斑点追踪成像技术分析急性心肌梗死模型犬的心脏功能,探讨其临床应用价值.方法 选取成年杂种犬27只,行外科手术开胸并结扎阻断左前降支中段血流以构建动物急性心肌梗死模型.分别于建模前及建模后1周行超声心动图检查,测量左室收缩末期和舒张末期内径;应用二维Simpson法测量左室容积和射血分数;应用仪器自带的分析软件计算犬心肌梗死前后的左室纵向应变.结果 与心肌梗死前比较,心肌梗死后犬左室收缩末期容积明显增加,左室射血分数明显降低,差异均有统计学意义(均P<0.05);其余参数比较差异均无统计学意义.心肌梗死后犬间隔和侧壁中间段,前壁及心尖各段的纵向应变均明显减低,差异均有统计学意义(均P<0.05);其余节段纵向应变比较差异均无统计学意义.结论 二维斑点追踪成像技术分析心肌的纵向应变可提示急性心肌梗死犬的心肌形变能力明显减低,有重要临床应用价值.%Objective To evaluate the cardiac function in acute myocardial infarction(AMI) canine by two-dimensional speckle tracking imaging,and to explore its clinical application value.Methods The study included a total of 27 healthy adult canines.AMI model was established by ligation of left anterior descending coronary artery.Echocardiography was performed before modeling and repeated one week after modeling.Left ventricular end-systolic diameter and left ventricular end-diastolic diameter were calculated.Left ventricular volumes and ejection fraction(LVEF) were measured by bi-plane Simpson method.And two-dimensional speckle tracking online analysis software was used to analyze the global longitudinal strain(LS). Results Left ventricular end-systolic volume was increased and LVEF was decreased significantly compared with the preoperative results , there were significant difference(all P<0 . 05). The LS of other myocardial segments were not statistically different.LS of septum and lateral wall in middle level,anterior wall and every segments in apex level were decreased after AMI compared with those before AMI,there were significant difference(all P<0.05).The LS of other myocardial segments were not statistically different.Conclusion Deformation ability reduction after AMI can be found by analyzing the LS using two-dimensional speckle tracking imaging,which has important clinical application value.
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