Objective To investigate the clinical value of serum 5'-NT, TBA combined with MAO in the diagnosis of liver tumors. Methods 250 patients with liver disease treated in our hospital from May 2014 to May 2016 were selected as the observation group. The patients were divided into three groups according to the type of disease:liver tumor group, chronic hepatitis group, cirrhosis group, severe hepatitis group, acute hepatitis group and type Hepatitis group; and then select the same period to our hospital for physical examination of 100 cases as a control group. Serum levels of 5'-NT, TBA, MAO, AST, ALT and GGT were detected in each group and compared with each other.Results The levels of TBA, AST,ALT and GGT in 250 patients were significantly higher than those in the control group (P0.05).The levels of MAO in liver tumor group and cirrhosis group were significantly higher than those in control group (P0.05).The levels of serum 5'-NT in chronic hepatitis group, cirrhosis group, severe hepatitis group, acute hepatitis group and hepatitis C group were lower than those in liver tumor group (P0.05).肝肿瘤组和肝硬化组MAO水平均高于对照组,差异有统计学意义(P0.05).慢性肝炎组、肝硬化组、重型肝炎组、急性肝炎组和丙型肝炎组血清5′-NT水平均低于肝肿瘤组,差异有统计学意义(P<0.05);重型肝炎组TBA水平高于肝肿瘤组,急性肝炎组和丙型肝炎组TBA水平均低于肝肿瘤组,差异有统计学意义(P<0.05);慢性肝炎组、重型肝炎组、急性肝炎组和丙型肝炎组MAO水平均低于肝肿瘤组,差异有统计学意义(P<0.05);慢性肝炎组、重型肝炎组和急性肝炎组ALT水平均高于肝肿瘤组,差异有统计学意义(P<0.05);肝硬化组、重型肝炎组、急性肝炎组和丙型肝炎组GGT水平均低于肝肿瘤组,差异有统计学意义(P<0.05).结论 血清5′-NT、TBA 与MAO检测在肝肿瘤诊断中对患者的肝脏分泌、合成和代谢功能具有较高敏感性,血清5′-NT、TBA 、MAO、AST、ALT和GGT水平可有效反映肝功能损伤程度,可为肝病患者的鉴别诊断提供可靠依据.
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