目的：探讨过氧化物酶体增殖物激活受体γ辅激活因子1α（PGC-1α）与乳腺癌发生及发展的相关性。方法乳腺癌患者和同期非乳腺癌患者各86例，采用免疫组化检测组织中PGC-1α蛋白表达水平，分析 PGC-1α与乳腺癌发生的相关性，针对乳腺癌患者不同病理分期、淋巴结转移情况分组，观察 PGC-1α与乳腺癌发生、发展的关系。结果乳腺癌患者 PGC-1α表达水平高于非乳腺癌患者，Ⅲ、Ⅳ期乳腺癌 PGC-1α表达水平高于Ⅰ、Ⅱ期乳腺癌患者，淋巴结转移阳性组PGC-1α的表达水平高于淋巴结转移阴性组，差异均有统计学意义（P <0.05）。采用 Logistic 回归分析 PGC-1α与乳腺癌发生、病理分期、淋巴结转移的相关性，差异均有统计学意义（P <0.05），且各项指标最大似然估计值和 OR 值均>0。结论 PGC-1α表达水平与乳腺癌的发生、病理分期、淋巴结转移呈正相关，有可能作为乳腺癌诊断和判断预后的指标。%Objective To investigate the relationship between PGC-1αand pathogenesis in breast cancer. Method A total of 86 cases of breast cancer patients and 86 cases of non-breast cancer patients were enrolled. The expression level of PGC-1α was examined by immunohistochemistry. The correlation between PGC-1αand breast cancer was analyzed. At the same time,patients with different pathological staging and metastasis of lymph node were grouped for analysis. The relationship between PGC-1α and pathogenesis in breast cancer was analyzed. Results The expression level of PGC-1α in breast cancer pa-tients was higher than the controls. Patients in stage Ⅲ and Ⅳ had higher levels of PGC-1α than patients in stageⅠand Ⅱ. Patients with lymphatic metastasis had higher levels of PGC-1α than patients without it (P < 0. 05). Logistic regression analysis revealed that PGC-1α was positively related to the occurrence, pathological stage and lymphatic metastasis of breast cancer(P < 0. 05). The maximum likelihood estimate value and OR value of each index were more than 0. Conclusion PGC-1α was positively related to the occurrence,physiological stages and lymph node metastasis in breast cancer.
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