几种再矿化牙膏对釉质再矿化影响的体外研究

摘要

目的:比较三种生物活性牙膏(精氨酸专效抗敏牙膏、GC护牙素、奥敏清脱敏糊剂)对牙釉质再矿化/脱矿作用的影响.方法:建立釉质早期龋坏模型,经过15 d pH循环及耐酸性试验后,测定牙釉质在不同时间点的表面硬度(SMH)值,并进行统计学分析.结果:经pH循环后,三组牙膏处理组牙釉质的SMH值均显著高于对照组(P＜0.001),耐酸性实验后,各组的SMH值显著下降(P＜0.05),牙膏处理组牙釉质的SMH值下降较少.pH循环及耐酸性实验后,精氨酸组和奥敏清组的SMH值均比GC护牙素组高(P＜0.05),精氨酸组和奥敏清组相比较,差异无统计学意义.结论:三种牙膏都可促进脱矿牙釉质再矿化,抑制酸性环境下的脱矿.精氨酸专效抗敏牙膏和奥敏清脱敏糊剂较GC护牙素有更好的再矿化潜能,减少釉质脱矿.%Objective:The aim of the study was to compare the effect of different bioactive element containing toothpastes(Pro-ArginTM,GC Tooth Mousse and NovaMin?)on demineralization/remineralization of enamel.Methods:Creating the artificial incipient carious lesion model,after 15 days pH-cycling and acid resistance testing,surface hardness of the samples was assessed using the Knoop hardness test at different time points.Data were analyzed using SPSS software 17.0.Results:After pH-cycling,the surface hardness values in treatment groups were significantly higher than the control group(P＜0.001).After acid resistance testing,all groups showed a significant loss of surface hardness(P＜0.05),the decrease in treatment groups were significantly lower than the control group.No significant difference was found in surface hardness between Pro-ArginTM and NovaMin? group during the pH-cycling test and acid resistance test.Conclusion:The three toothpastes showed remineralization potential,Colgate Sensitive Pro-Relief and NovaMin present an advantage in enhancing remineralization and inhibition demineralization for early enamel carious lesions in comparison with GC Tooth Mousse.