目的：探究3种市售无氟儿童牙膏即生物活性玻璃儿童牙膏、双黄连儿童牙膏、木糖醇儿童牙膏对乳牙早期釉质龋的再矿化作用。方法应用离体乳牙制备人工龋模型50例，随机分为5组：活性玻璃组、双黄连组、木糖醇组、NaF 组、去离子水组。在体外进行pH 循环后，测量各组乳牙的表面显微硬度，并结合偏光显微镜对乳牙的釉质龋损进行形态学观察。结果活性玻璃组能显著提高乳牙早期釉质龋再矿化后的表面显微硬度（P ＜0．05），但其提高的程度不如NaF 组（P ＜0．05），双黄连组、木糖醇组和去离子水组未能提高再矿化后的显微硬度（P ＜0．05）。偏光显微镜下，活性玻璃组与NaF 组再矿化后乳牙表层釉质的脱矿深度明显变浅。结论生物活性玻璃儿童牙膏能有效促进乳牙早期釉质龋再矿化，但其再矿化能力小于含氟牙膏，双黄连儿童牙膏和木糖醇儿童牙膏在本次实验中未能体现出再矿化能力。%Objective To evaluate the remineralization of initial enamel caries on primary teeth by three children′s non-fluoride toothpastes. Methods 50 artificial caries models were created from primary teeth,which were then randomly distributed into 5 groups, namely bioactive glass group,Shuanghuanglian group,xylitol group,NaF group,and deionized water group. The specimens were subjec-ted to a PH-cycling regime for 7 days. Surface enamel microhardness was measured by microhardness tester,and morphologic changes of enamel carious lesions were detected by polarized light microscopy. Results Surface microhardness of bioactive glass group was signif-icantly higher after remineralization (P < 0. 05),but not as much as that of NaF group (P < 0. 05). Meanwhile,microhardness didn′t improve in xylitol group,Shuanghuanglian group or deionized water group (P < 0. 05). Polarized light microscopy showed the depth of demineralization lesion obviously reduced in both bioactive glass group and NaF group. Conclusions Bioactive glass children′s tooth-pastes can obviously promote the remineralization of initial enamel caries on primary teeth,but the remineralization ability is inferior to that of NaF toothpastes. Besides,Shuanghuanglian children′s toothpastes and xylitol children′s toothpastes demonstrate no ability of remineralization in this research.
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