[Objective] To explore the correlation between individuality, mental health status and cytokines interleukin-1 (IL-1), interleukin-6(IL-6) and tumor necrosis factor-alpha(TNF- α) in patients with hyperthyroidism before treatment with 131 I. [Methods] Eysenck personality questionnaire(EPQ) and status of mental health(SCL-90) in 48 patients with hyperthy roidism before treatment with 131 I and 40 healthy people were evaluated. Radioimmunoassay was used to determine the levels of IL-1, IL-6 and TNF-α in peripheral blood before treatment. The correlation between each factors of EPQ and SCL 90 and set um changes of IL-1, IL-6 and TNF-α were analyzed. [Results] The spirit(P) and neuroticism(N) scores in patients with hy perthyroidism before treatment with 131 I were obviously higher than those in control group( P ＜0.05, P ＜0.01). Most of pa tients with hyperthyroidism were considered as depressed personality, while most of normal controls were regarded as sanguine and phlegmatic personality. The symptom factor scores of SCL-90 in patients with hyperthyroidism were significantly higher than those in control group( P ＜0.05, P ＜0.01). There was no statistical significance in serum IL-1 level between patients with hyperthyroidism before treatment with 131I and control group( P ＞0.05). Serum IL-6 and TNF-α levels in patients with hyperthyroidism before treatment with 131I were higher than those in control group( P ＜0.05). Correlation analysis showed that IL-1 was negatively related with character and SCL-90(r=- 0.73,-0.53,-0.39,-0.86,-0.31,-0.97, P ＜0.05,P＜0.01). IL-6 was negatively correlated with character and SCL-90(r=-0.64,-0.54,-0.61,-0.45,-0.76,-0.31,-0.36, -0.66, -0.51,P＜0.05,P＜0.01). TNF-α was positively correlated with character and SCL-90(r= 0.43, 0.82,0.29, P ＜0.05, P ＜0.01). [Conclusion]The patients with hyperthyroidism have indrawn, unstable and nervous personality,and also have some problems in emotion. Their mental health status in overall is poorer. Serum levels of IL-1, IL-6 and TNF-α have obvious changes in the pathogenesis of hyperthyroidism and are significantly correlated with the personality and mental health status of patients.%[目的] 探讨甲亢131碘治疗前患者的个性及心理健康状况与细胞因子白介素(IL-1、IL-6)和肿瘤坏死因子-α(TNF-α)的关系.[方法]对48例甲亢131碘治疗前患者和40例正常对照组,进行艾森克人格(EPQ)和心理健康状况(SCL-90)评定;用放射免疫分析法检测治疗前外周血IL-1、IL-6、TNF-α水平,对比分析人格和SCL-90各因子与血清IL-1、IL-6和TNF-α变化的相关性.[结果]甲亢131碘治疗前患者的精神度(P)和神经质(N)分值显著高于正常对照组(P<0.05 、0.01);甲亢患者多属于抑郁质人格,而对照组多属于多血质和粘液质人格特质;甲亢患者SCL-90症状因子分所有指标分值均显著高于对照组(P<0.05、P<0.01).甲亢131碘治疗前患者血清IL-1水平与对照组无统计学意义(P＞0.05);血清IL-6及TNF-α水平高于对照组(P<0.05).相关性分析显示:IL-1与性格及SCL-90呈负相关(r=-0.73、-0.53、-0.39、-0.86、-0.31、-0.97,P<0.05、P<0.01);IL-6与性格及SCL-90呈负相关(r=-0.64、-0.54、-0.61、-0.45、-0.76、-0.31、-0.36、-0.66、-0.51,P<0.05、P<0.01);TNF-α与性格及SCL-90呈正相关(r=0.43、0.82、0.29,P<0.05、P<0.01).[结论] 甲亢患者具有内向不稳定型及神经质的人格特征,在情绪方面存在一定问题,总体心理健康状况较差;在甲亢发病中,血清IL-1、IL-6和TNF-α有明显变化,而且与患者个性特征和心理健康水平均有显著相关性.
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