Model of Iodine Metabolism in a T sub 3 -Thyrotoxic Patient Undergoing I-131Therapy.

摘要

Data on radioactivity in the thyroid,urine,serum,butanol-extractable iodine (BEI) and chromatographic fractionations of BEI,obtained during four I-131therapeutic treatments of a T sub 3 -thyrotoxic patient,have been analyzed and simulated with the help of a 7-compartment model. Good fits to most of the data can be obtained with both the dose-independent and dose-dependent models. A model with 3or 4compartments,which provides adequate fits to iodine kinetic data in most euthyroid and hyperthyroid patients is not satisfactory in the case of this patient. Thus,to represent iodine metabolism during T sub 3 -thyrotoxicosis therapy,we find that it is necessary to provide for separate biochemical pathways for the BEI components as well as the butanol-insoluble compounds released by the thyroid gland. (ERA citation 01:021269)