Objective To observe the characteristic of Th1/Th2 unbalance in patients with chronic obstructive pulmonary disease. Method The serum level of IFN-γ and IL-4,which reflect the function of Thl and Th2 lymphocyte respectively, were detected in 56 patients with COPD in acute exacerbation stage and in stable stage respectively, and the results were compared between different stages,also with that of heath control group. Results The serum level of IFN-γ and IL-4 increased significantly in AECOPD than that in control group( P ＜0. 05 ) ,but only the level of IFN-γ was higher in stable COPD when compared with control group. There was an increased IL-4 ( P ＜ 0. 05 ) and an equal IFN-γ( P ＞ 0. 05 ) level in AECOPD when compared with stable COPD. Conclusion There is a predominanea of Th1 in stable COPD, and a drift to Th2 in AECOPD, when Th1/Th2 balance is eoneemed.%目的 观察慢性阻塞性肺疾病Th淋巴细胞亚群平衡失调特点.方法 分别于56例患者疾病急性加重期及稳定期测定反映Th1淋巴细胞功能的IFN-γ及反映Th2淋巴细胞功能的IL-4血清水平,比较急性加重期及稳定期上述炎症因子水平差异,并将其与同年龄健康对照组进行比较.结果 与对照组比较,稳定期COPD患者IL-4水平无显著差异(P>0.05)而IFN-γ显著增高(P<0.05).而急性期COPD患者IL-4及IFN-γ水平均较对照组明显增高(p均<0.05).与稳定期相比,急性期血浆IL-4水平明显增高(P<0.05)而IFN-γ水平并无显著性差异(P>0.05).结论 稳定期COPD患者存在Th1淋巴细胞功能亢进,而急性加重期Th1/ Th2平衡有向Th2漂移的特点.
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