黄精多糖对哮喘患者血清总IgE、IL-4、INF-γ及肺功能的影响

摘要

Objective To investigate the effect of Yellow refined polysaccharides on serum total IgE , IL4 , INF-y and lung lunc-tion in patients with asthma. Methods 60 rases of patients with acute exacerbation of asthma, were randomly divided into treatment group and control group, 30 cases in each group, all the patients were given the corresponding level doses of glucocoiticoids and other conventional treatment, and yellow refined polysacchaiides in the treatment group on the basis of conventional therapy, monthly lor 7 days, the course was 3 months. All patients before treatment and after treatment lor 3 months, detection of total serum IgE , IL4 , INF-y concentration , and the determination of lung function ( FE V, % and PEF% ) were made. Results Compared with before treatment, the treatment group patients serum total IgE, IL4 content significantly decreased ( P < 0. 01 ); serum INF-y level increased significantly ( P < 0. 01 ), lung function improved significantly ( P <0. 01 ). Compared with the control group, the total serum IgE and IL4 levels of treatment group patients were significantly reduced ( P<0. 05 ); serum INF --y level increased significantly ( P <0. 01 ), lung function improved significantly ( P < 0. 05 ). Conclusion The Yellow refined polysacchaiides can improve lung function in patients with acute exacerbation of asthma, and can reduce the total serum IgE and IL4 levels, thereby reducing the airway hyperresponsiveness in patients with asthma.%目的 探讨黄精多糖对哮喘患者血清总IgE、IL-4、INF-γ及肺功能的影响.方法 选择哮喘急性发作期患者60例,随机分为治疗组和对照组,每组各30例,所有患者均给予相对应级别剂量的糖皮质激素等常规治疗,黄精多糖治疗组于常规治疗基础上加用黄精多糖注射液,每月连续用7天,疗程3个月.所有患者在治疗前及治疗3个月后检测血清总IgE、IL-4、INF-γ浓度,并测定肺功能(FEV1%和PEF%).结果 与治疗前比较,治疗组患者血清总IgE、IL-4含量较治疗前明显降低(P＜0.01);血清INF-γ水平显著升高(P＜0.01),肺功能明显改善(P＜0.01).与对照组比较,治疗组患者血清总IgE和IL-4含量明显降低(P＜0.05);血清INF-γ水平显著升高(P＜0.01),肺功能明显改善(P＜0.05).结论 黄精多糖能有效改善急性发作期哮喘患者肺功能,并能降低血清总IgE和IL-4水平,从而降低哮喘患者的气道高反应性.