目的 探讨肺癌患者血浆D-二聚体和纤维蛋白原水平的变化及临床意义.方法 测定80例肺癌患者(肺癌组)及46例健康体验者(对照组)血浆D-二聚体、纤维蛋白原水平并进行对比分析.结果 肺癌组血浆D-二聚体、纤维蛋白原水平高于对照组(P＜0.05).肺癌组血浆D-二聚体、纤维蛋白原与病理类型、TNM分期之间无明显关系.治疗缓解组较初治组和复发难治组纤维蛋白原和D-二聚体水平均有下降(P＜0.05).结论 检测肺癌患者血浆D-二聚体及纤维蛋白原水平,可用作判断其体内高凝和纤溶状态,预测其血栓发生的危险程度,估计病情发展状况的依据.%Objective To investigate the content change and its significance oi D-dimer and iibrinogen in the treatment oi lung ranrer patients. Methods 80 patients with lung ranrer were selected as the lung cancer group and 46 healthy people were taken as the controls. The plasma levels oi fibrinogen and D-dimer were detected and compared between the two groups. Results. The levels oi D-dimer and iibrinogen were significantly higher in the lung cancel' group than in the control group ( P < 0. 05 ). There was no obvious relationship oi the levels oi D-dimer and iibrinogen to histological classification and P-TNM stages. The levels oi iibrinogen and D-dimer both decreased in the complete remission group and the relapse group ( P <0. 05 ). Conclusion The detection oi D-dimer and iibrinogen levels in patients with lung cancer can be used to judge the body coagulation and fibrinolysis. Besides, it can predict the risk oi thrombosis level and estimated disease development.
展开▼
