Objective To investigate the clinical efficacy of sildenafil citrate in the treatment of pulmonary hypertension during pregnancy. Methods 97 pregnant patients complicated with PAH in our hospital were randomly divided into the observation group (47 cases) and the control group (50 cases). All patients were given conventional treatment, and the observation group was additionally treated with sildenafil citrate. The changes of pregnancy out-come, blood gas analysis and blood dynamics, blood coagulation and biochemical indexes were observed and com-pared between the two groups before and after the treatment, and their cardiac function and PAH outcome were also recorded. Results After the treatment, their pregnancy outcome, left ventricular ejection fraction, oxygen partial pressure and saturation of blood oxygen were obviously better in the observation group than in the control group ( P<0. 05 ) . The progress in PAH level and heart function was more pronounced in the observation group than in the con-trol group (P<0. 05). Conclusion Sildenafil citrate therapy has satisfying curative effect in the treatment of pul-monary hypertension during pregnancy, which can improve hemodynamic and blood gas indexes and prevent heart function and PAH aggravation.%目的 探讨枸橼酸西地那治疗妊娠合并肺动脉高压患者的临床疗效. 方法 将我院97例妊娠合并PAH的患者随机分为观察组47例及对照组50例,两组患者均给予常规治疗,观察组患者同时给予枸橼酸西地那非,观察两组患者的妊娠结局及各项指标变化情况,以及心功能及PAH转归情况. 结果 治疗后观察组患者的妊娠结局显著优于对照组,同时左室射血分数、氧分压、血氧饱和度显著优于对照组患者,差异均具有统计学意义(P<0. 05);并且对照组患者经过治疗PAH程度及心功能进展的例数显著高于观察组患者,差异具有统计学意义(P<0. 05). 结论 枸橼酸西地那非治疗妊娠合并肺动脉高压效果理想,能够改善患者的各项指标及妊娠结局,阻止心功能及PAH的进一步加重.
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